The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium

ELife
Ellen N ElliottKlaus H Kaestner

Abstract

Dnmt1 is critical for immediate postnatal intestinal development, but is not required for the survival of the adult intestinal epithelium, the only rapidly dividing somatic tissue for which this has been shown. Acute Dnmt1 deletion elicits dramatic hypomethylation and genomic instability. Recovery of DNA methylation state and intestinal health is dependent on the de novo methyltransferase Dnmt3b. Ablation of both Dnmt1 and Dnmt3b in the intestinal epithelium is lethal, while deletion of either Dnmt1 or Dnmt3b has no effect on survival. These results demonstrate that Dnmt1 and Dnmt3b cooperate to maintain DNA methylation and genomic integrity in the intestinal epithelium.

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Citations

Dec 6, 2016·International Journal of Molecular Sciences·Ilaria FlorisIllimar Altosaar
Dec 6, 2016·Diabetes Research and Clinical Practice·Diana BernsteinKlaus H Kaestner
Jun 21, 2017·Journal of Lipid Research·Shunxing RongLuke J Engelking
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Methods Mentioned

BETA
laser capture microdissection
laser-capture microdissection
PCR

Software Mentioned

GraphPad Prism

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