The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

Immunity
M A KelliherP Leder

Abstract

The death domain serine/threonine kinase RIP interacts with the death receptors Fas and tumor necrosis receptor 1 (TNFR1). In vitro, RIP stimulates apoptosis, SAPK/JNK, and NF-kappaB activation. To define the physiologic role(s) that RIP plays in regulating apoptosis in vivo, we introduced a rip null mutation in mice through homologous recombination. RIP-deficient mice appear normal at birth but fail to thrive, displaying extensive apoptosis in both the lymphoid and adipose tissue and dying at 1-3 days of age. In contrast to a normal thymic anti-Fas response, rip-/- cells are highly sensitive to TNFalpha-induced cell death. Sensitivity to TNFalpha-mediated cell death in rip-/- cells is accompanied by a failure to activate the transcription factor NF-kappaB.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LewisD V Goeddel
Oct 28, 1988·Science·P A Baeuerle, D Baltimore
Apr 29, 1994·Science·P D CroweC A Smith
Nov 28, 1996·Nature·J KitsonS N Farrow
Jan 2, 1997·Nature·H Duan, V M Dixit
Feb 7, 1997·Cell·S Nagata
Jul 25, 1997·Cell·C H RégnierM Rothe

❮ Previous
Next ❯

Citations

Mar 26, 1999·European Journal of Immunology·E DudleyM Lenardo
Jul 13, 2000·Microscopy Research and Technique·M J Smyth, R W Johnstone
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W A Faubion, G J Gores
Jan 24, 2006·Anatomy and Embryology·Lijun ZhaoYing Li
Jul 24, 2010·Molecules and Cells·Michael J Morgan, Zheng-Gang Liu
Jul 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·Sabine GröbnerIngo B Autenrieth
Nov 22, 2007·Breast Cancer Research and Treatment·Claudio LuparelloBruna Lo Sasso
Jun 20, 2006·Journal of Clinical Immunology·Sudhir GuptaSastry Gollapudi
Nov 1, 2011·Immunologic Research·Jianke ZhangMathew Farabaugh
Apr 6, 2012·Immunologic Research·Marie Anne O'Donnell, Adrian T Ting
Jan 24, 2004·Brain Research. Brain Research Reviews·Chulhee Choi, Etty N Benveniste
Feb 14, 2004·Cellular Immunology·Rita N BárciaJulie D McLeod
Jun 8, 2012·Cell Reports·Christopher P DillonDouglas R Green
Dec 31, 2003·Molecular Immunology·Silvia Naitza, Petros Ligoxygakis
Sep 29, 2000·Biochemical Pharmacology·B B Aggarwal
Sep 23, 2000·Chemistry and Physics of Lipids·M Krönke
Apr 26, 2003·Mechanisms of Ageing and Development·Sudhir GuptaSastry Gollapudi
Jul 19, 2002·Advances in Enzyme Regulation·Jorge Moscat, María T Diaz-Meco
May 2, 2002·Cell·Sankar Ghosh, Michael Karin
Mar 8, 2000·Progress in Neurobiology·G L Barrett
Apr 23, 2003·Cancer Letters·Young-Ju JangHyung-Il Kim
Mar 12, 2003·Toxicology Letters·Marion MacFarlane
Mar 19, 2002·Cellular Signalling·David J MacEwan
Apr 27, 2000·Current Opinion in Immunology·G Screaton, X N Xu
Jan 23, 1999·Current Opinion in Immunology·A P Cope
Jun 25, 1998·Current Opinion in Immunology·D WallachM P Boldin
Oct 31, 1998·Current Opinion in Immunology·M E Peter, P H Krammer
Apr 21, 1999·Current Opinion in Cell Biology·A Ashkenazi, V M Dixit
Aug 26, 1998·Current Biology : CB·M ThomeJ Tschopp
Aug 22, 2001·Trends in Cell Biology·V Baud, M Karin
Mar 26, 2003·Seminars in Cancer Biology·Nesrin Ozören, Wafik S El-Deiry
Feb 28, 2002·Molecular Cell·Guoqing ChenDavid V Goeddel
Feb 13, 2001·The International Journal of Biochemistry & Cell Biology·H Wajant, P Scheurich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.