The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.

The Journal of Biological Chemistry
Yinyin LiuZhou Songyang

Abstract

The regulatory network of factors that center on master transcription factors such as Oct4, Nanog, and Sox2 help maintain embryonic stem (ES) cells and ensure their pluripotency. The target genes of these master transcription factors define the ES cell transcriptional landscape. In this study, we report our findings that Dido1, a target of canonical transcription factors such as Oct4, Sox2, and Nanog, plays an important role in regulating ES cell maintenance. We found that depletion of Dido1 in mouse ES cells led to differentiation, and ectopic expression of Dido1 inhibited differentiation induced by leukemia inhibitory factor withdrawal. We further demonstrated that whereas Nanog and Oct4 could occupy the Dido1 locus and promote its transcription, Dido1 could also target to the loci of pluripotency factors such as Nanog and Oct4 and positively regulate their expression. Through this feedback and feedforward loop, Dido1 is able to regulate self-renewal of mouse ES cells.

References

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D García-DomingoC Martínez-A
Nov 20, 2001·Stem Cells·J Rossant
Sep 11, 2002·Trends in Cell Biology·Tom BurdonPierre Savatier
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Apr 17, 2003·Molecular and Cellular Biology·David García-DomingoCarlos Martínez-A
Feb 3, 2004·Genesis : the Journal of Genetics and Development·Jeong-Heon LeeDavid G Skalnik
Sep 21, 2004·Oncogene·Ian Chambers, Austin Smith
Aug 30, 2005·The Journal of Clinical Investigation·Agnes FüttererCarlos Martínez-A
Sep 13, 2005·Cell·Laurie A BoyerRichard A Young
May 27, 2006·Nature·Pedro V PeñaTatiana G Kutateladze
Nov 10, 2006·Nature·Jianlong WangStuart H Orkin
Feb 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Varvara TrachanaCarlos Martínez-A
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Nov 22, 2007·Science·Junying YuJames A Thomson
Dec 22, 2007·Nature·Ian ChambersAustin Smith
Feb 27, 2008·Acta Pharmacologica Sinica·Yong WangQiu-ling Wu
Jul 10, 2009·Nature·Alexandre Gaspar-MaiaMiguel Ramalho-Santos
Aug 26, 2009·Cell·Jose SilvaAustin Smith
Apr 7, 2010·Cell Stem Cell·Debbie L C van den BergRaymond A Poot
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Alexandre Gaspar-MaiaMiguel Ramalho-Santos
Jun 15, 2011·Cell·Stuart H Orkin, Konrad Hochedlinger

❮ Previous
Next ❯

Citations

Aug 2, 2015·Clinical & Experimental Metastasis·Fabiola CecchiDonald P Bottaro
Aug 9, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sally A MayasichBenjamin L Clarke
Feb 28, 2019·Molecular Genetics & Genomic Medicine·Jessada ThutkawkorapinEmma Tham
Apr 24, 2020·Nucleic Acids Research·Tristan CardonMichel Salzet
Apr 20, 2019·Scientific Reports·Christopher J PetellBrian D Strahl
Apr 19, 2021·Current Treatment Options in Oncology·Piotr Kraj
Jul 25, 2021·International Journal of Molecular Sciences·Roberto QuadriMarco Muzi-Falconi

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.