May 10, 2016

The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem

BioRxiv : the Preprint Server for Biology
Mehdi MaadooliatSteven J Schrodi

Abstract

Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site. A complete description of this two-locus system is of particular importance to experimental efforts to fine map association signals for complex diseases. Here, we present a simple relationship between disease association statistics and the decline of linkage disequilibrium from a causal site. A complete derivation of this relationship from a general disease model is shown for very large sample sizes. Quite interestingly, this relationship holds across all modes of inheritance. Extensive Monte Carlo simulations using a disease genetics model applied to chromosomes subjected to a standard model of recombination are employed to better understand the variation around this fine mapping theorem due to sampling effects. We also use this relationship to provide a framework for estimating properties of a non-interrogated causal site using data at closely linked markers. We anticipate that understanding the patterns of disease association decay with declining linkage disequilibrium from a causal site will enable mor...Continue Reading

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Mentioned in this Paper

Biological Markers
Patterns
Dysequilibrium Syndrome
Recombination, Genetic
Dicom Derivation
Genetic Inheritance
Site
Chromosomes
Description
Simulation

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