The decline in kidney function with chromium exposure is exacerbated with co-exposure to lead and cadmium

Kidney International
Tsung-Lin TsaiShu-Li Wang

Abstract

Environmental factors contribute significantly to the pathogenesis of chronic kidney disease. However, these factors, and particularly the toxic effects of heavy metals, have not been completely evaluated. Chromium is a widespread industrial contaminant that has been linked to nephrotoxicity in animal and occupational population studies. Nevertheless, its role in population renal health and its potential interactions with other nephrotoxic metals, such as lead and cadmium, remain unknown. We assessed the association between exposure to chromium, lead, and cadmium with renal function using estimated glomerular filtration rate (eGFR) in an analysis of 360 Taiwanese adults aged 19-84 years from the National Nutrition and Health Survey in Taiwan (2005-2008). Doubling of urinary chromium or lead decreased the eGFR by -5.99 mL/min/1.73 m2 (95% confidence interval -9.70, -2.27) and -6.61 (-9.71, -3.51), respectively, after adjusting for age, sex, body mass index, hypertension, diabetes, cigarette smoking, sodium intake, education, urinary volume, and other metals. For those in the highest tertile of cadmium exposure, the eGFR decreased by -12.68 mL/min/1.73 m2 (95% confidence interval -20.44, -4.93) and -11.22 mL/min/1.73 m2 (-17.01, ...Continue Reading

References

Jul 1, 1995·Lancet·G D NuytsM E De Broe
May 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M S WuH C Chien
May 1, 1996·American Journal of Industrial Medicine·K SteenlandN Simonsen
Dec 16, 1998·Journal of the American College of Nutrition·R A Anderson
Jun 29, 1999·Journal of Toxicology. Clinical Toxicology·Y LoubièresF Jardin
Sep 13, 2000·Occupational and Environmental Medicine·L JärupC G Elinder
Oct 10, 2002·International Archives of Occupational and Environmental Health·Ven-Shing WangJim-Shoung Lai
Mar 13, 2003·Kidney International·Kunitoshi IsekiShuichi Takishita
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Melanie K HarounJosef Coresh
Aug 18, 2005·Journal of Exposure Science & Environmental Epidemiology·Feng-Hsiang ChangLouis W Chang
Feb 24, 2006·The Annals of Pharmacotherapy·Sachin WaniLeslie Spry
Oct 26, 2006·Kidney International·E B EkongV M Weaver
Jan 2, 2009·Journal of the American Society of Nephrology : JASN·Stephanie J Leuenroth, Craig M Crews
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 25, 2009·American Journal of Epidemiology·Ana Navas-AcienVirginia Weaver
Nov 17, 2009·Ecotoxicology and Environmental Safety·Nejla SoudaniNajiba Zeghal
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Mingai HuangJung-Duck Park
Apr 1, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Nikhil JohriRobert Unwin
Jul 9, 2010·Nephrology·Shang-Jyh HwangHung-Chun Chen
Aug 19, 2010·International Archives of Occupational and Environmental Health·Tiancheng WangSen Zhen
Jul 6, 2011·BMC Nephrology·Kamani P WanigasuriyaRajitha Wickremasinghe
Oct 14, 2011·Kidney International·William G CouserMarcello Tonelli
May 10, 2012·JAMA : the Journal of the American Medical Association·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Aug 17, 2012·Toxicology Mechanisms and Methods·Qinghua JiaXiaopeng Yang
Mar 20, 2013·International Journal of Molecular Sciences·Ambily Ravindran NairAnn Cuypers
Apr 5, 2013·BioMed Research International·Wen-Hung HuangTzung-Hai Yen
Apr 12, 2013·Oxidative Medicine and Cellular Longevity·Zhang YiranLiu Zongping
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Feb 20, 2014·Ageing Research Reviews·Davide BolignanoCarmine Zoccali
Jul 16, 2014·International Journal of Environmental Research and Public Health·Annamaria NicolliAndrea Trevisan
Jun 24, 2015·Nature Reviews. Nephrology·Anglina KatariaHoward Trachtman
Jul 15, 2015·Journal of Exposure Science & Environmental Epidemiology·Tsung-Lin TsaiShu-Li Wang

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Citations

Mar 3, 2018·Journal of Toxicology and Environmental Health. Part a·Sarah E OrrChristy C Bridges
Aug 29, 2019·Environmental Science and Pollution Research International·Muhammad Ahsan RiazKhurram Shahzad
Jul 26, 2019·Environmental Science and Pollution Research International·Hao-Long ZengLiming Cheng
Jan 7, 2019·Environmental Science and Pollution Research International·Kai-Wei LiaoShu-Li Wang
Mar 1, 2019·Environmental Geochemistry and Health·M R D L KulathungaA W Wijeratne
Aug 7, 2019·BMC Nephrology·Ching-Wei HsuWen-Hung Huang
Jul 7, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Jeonghwan LeeJung Pyo Lee
Mar 7, 2021·Diagnostics·Hui-Ju TsaiChao-Hung Kuo
Jun 6, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sameera A GunawardenaSaroj Jayasinghe
Apr 12, 2021·Environmental Science and Pollution Research International·Zihan ChenXijin Xu
Aug 2, 2020·Ecotoxicology and Environmental Safety·Chien-Yu LinTa-Chen Su
May 29, 2021·The American Journal of the Medical Sciences·Daniel Glicklich, William H Frishman
Aug 28, 2021·Children·Yuri Levin-SchwartzAlison P Sanders
Aug 16, 2017·Kidney International·Joseph Lunyera, Stephen R Smith
Nov 24, 2021·Advanced Healthcare Materials·Angela M GutierrezJ Zach Hilt

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