The decline of the photopic negative response (PhNR) in the rat after optic nerve transection

Documenta Ophthalmologica. Advances in Ophthalmology
B LiW F Holt

Abstract

To investigate the contribution to the photopic negative response (PhNR) of the electroretinogram (ERG) by retinal ganglion cells (RGCs). The PhNR was assessed longitudinally following optic nerve transection (ONTx). Photopic ERGs were recorded from each eye of an anesthetized (ketamine/xylazine, 60 mg/kg and 5 mg/kg) Brown Norway rat using custom made electrodes (PT-IR Tef., A-M System Inc). ERGs were elicited using green Ganzfeld flashes (11.38 scd/m(2), 22.76 cds/m(2)) and a rod suppressing green-background (40 cd/m(2)). PhNRs were compared before and after optic nerves were transected. Cresyl violet stained retinal flatmounts were used to estimate cell loss in the ganglion cell layer 3 and 15 weeks after optic nerve transection. The pharmacological effect of 1.3 microM intravitreal TTX on the PhNR was also evaluated. There was a significant loss (p <0.05) in the PhNR of 20, 36, 34, 35, 48, 48 and 56% for ONTx eye versus the contralateral eye, at post ONTx times of 24 h, 1, 2, 3, 4, 8 and 15 weeks. B-wave amplitudes of ONTx eyes were not significantly different from the control eyes. In ONTx eyes, mean cell loss in the retinal ganglion cell layer was 27 and 55% at the 3 week and 15 week time periods. In the eyes with ONTx, t...Continue Reading

References

Jan 1, 1979·Vision Research·A Hughes
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M KorthJ Jonas
Mar 1, 1987·Documenta Ophthalmologica. Advances in Ophthalmology·V PorciattiG Moretti
May 1, 1983·American Journal of Ophthalmology·H A QuigleyW R Green
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Mansour-RobaeyA J Aguayo
Jun 1, 1996·Journal of Neurocytology·M Russelakis-CarneiroV H Perry
Jun 13, 2001·Current Eye Research·P DureauM Abitbol
Oct 28, 2003·The Journal of Physiology·Bang V Bui, Brad Fortune

❮ Previous
Next ❯

Citations

Nov 11, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Ido Perlman
Mar 25, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Benjamin J SmithFrançois Tremblay
Jan 25, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Hongling ChenDezheng Wu
Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Farzin ForooghianPaul O'Connor
Feb 24, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Oliver W GramlichFranz H Grus
Feb 13, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Paul A ConstableDorothy A Thompson
Apr 5, 2008·The Journal of Physiology·Deb Kumar MojumderLaura J Frishman
Aug 2, 2011·Experimental Eye Research·Alun R BarnardRobert E MacLaren
Mar 3, 2009·Experimental Eye Research·Gen MiuraLaura J Frishman
Jul 15, 2015·Journal of Neurosurgery·Hun Ho ParkJong Hee Chang
May 24, 2015·Experimental Eye Research·Vittorio Porciatti
Nov 7, 2014·Translational Vision Science & Technology·Jessica TangMarc Sarossy
Aug 24, 2010·Vision Research·Luis Alarcón-MartínezManuel Vidal-Sanz
Jul 16, 2014·Frontiers in Molecular Neuroscience·Anuradha DhingraNoga Vardi
May 25, 2016·Current Eye Research·Ahmed DellaaRafika Ben Chaouacha-Chekir
Aug 16, 2016·Experimental Eye Research·Ben Mead, Stanislav Tomarev
Sep 8, 2018·Investigative Ophthalmology & Visual Science·Chloe N ThomasZubair Ahmed
Mar 13, 2014·Journal of Neuropathology and Experimental Neurology·Radouil TzekovFiona Crawford
Feb 23, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Takashi OkunoHidehiro Oku
Jul 19, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Adriana BerezovskySolange Rios Salomão
Dec 16, 2020·Journal of Neuroinflammation·Pia GrotegutStephanie C Joachim
Nov 1, 2020·Experimental Eye Research·Ashutosh JnawaliLisa A Ostrin
Apr 18, 2020·Journal of the Neurological Sciences·Yung Ju YooChae-Yong Kim
Oct 17, 2019·Schizophrenia Research·Pantea MoghimiRobert F Miller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.