The decrease in nonsplenic interleukin-6 (IL-6) production after splenectomy indicates the existence of a positive feedback loop of IL-6 production during endotoxemia in dogs.

Infection and Immunity
H S MoeniralamJ A Romijn

Abstract

The spleen is involved in endotoxin-induced interleukin-6 (IL-6) production. To quantitate the relative contribution of the spleen to endotoxin-induced IL-6 production, we studied the effect of endotoxin (1.0 microg/kg of body weight) in control dogs (n = 7) and splenectomized dogs (n = 7). Blood for analysis of tumor necrosis factor (TNF) and IL-6 was sampled from the femoral artery and the portal, hepatic, and splenic (only in controls) veins. Arterial plasma endotoxin and cortisol levels were also measured. Whole-body IL-6 production was calculated by a deconvolution technique. Splenic IL-6 production in control dogs was measured from splenic blood flow and arteriovenous concentration differences. Endotoxin levels were higher in splenectomized dogs (P < 0.05) because of a decreased distribution volume (P < 0.05) and decreased clearance of endotoxin (P < 0.05). Endotoxin-induced plasma IL-6 levels were decreased by approximately 75% in splenectomized dogs (P < 0.01), and whole-body IL-6 production rates were severalfold lower (median of 8.7 mg/4 h and range of 3.9 to 11.4 mg/4 h versus a median of 32.3 mg/4 h and a range of 22.7 to 70.2 mg/4 h) (P < 0.05). However, in control dogs splenic IL-6 production (0.6 +/- 0.2 mg/4 h) ...Continue Reading

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Citations

May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A Romanovsky, Scott R Petersen
Sep 18, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M ParkL C P Azevedo
Jul 30, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Leonid Gibiansky, Ekaterina Gibiansky
Jun 22, 2001·Immunopharmacology and Immunotoxicology·M AltamuraS Miniello
Jul 1, 2010·Journal of Cellular Physiology·Katie J PorterNarayanan Parameswaran
Apr 12, 2012·Experimental Biology and Medicine·Megumi InoueHironobu Yoshimatsu
Nov 19, 1997·Journal of Endocrinological Investigation·H S MoeniralamJ A Romijn
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carlos FelederClark M Blatteis
Sep 2, 1998·The American Journal of Physiology·H S MoeniralamJ A Romijn
Jun 16, 2001·Journal of Applied Physiology·H S MoeniralamJ A Romijn
Feb 26, 2021·GeroScience·Mladen JergovićJanko Nikolich-Žugich
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·G TarantinoD Capone

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