PMID: 2495299Jan 1, 1989Paper

The defect in peripheral blood B-cell activation in patients with multiple myeloma is not due to a deficiency in the production of B-cell growth and differentiation factors

Journal of Clinical Immunology
T CommesR Bataille

Abstract

The suppression of B lymphopoiesis is a major feature of multiple myeloma (MM). In this disease, there is a striking defect in the response of peripheral blood B cells to pokeweed mitogen (PWM). Normally, B-cell activation depends on B-cell growth factors (BCGFs) and B-cell differentiation factors (BCDFs), produced by peripheral blood mononuclear cells. We therefore evaluated whether the production of these cytokines was defective in patients with MM. We have studied the production of BCGFs (using the anti-mu assay) and, particularly, interleukin-2 and interferon-gamma, two well-documented BCGFs. No defect in the production of BCGFs, interleukin-2, and interferon-gamma was found in patients with active (N = 14) or stable (N = 10) MM, compared with healthy donors (N = 13). The production of BCDFs (i.e., overall activity) was also evaluated and, more particularly, that of interleukin-6 (IL-6). This cytokine is a potent BCDF which is essential in the PWM-induced activation of B cells, acting at the terminal stages of B-cell differentiation. Again, no defect in the production of BCDFs and IL-6 was found in patients with MM. Therefore, the ability to secrete cytokines controlling the process of B-cell activation is not affected in s...Continue Reading

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Citations

Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·B Barlogie, J Epstein
Mar 1, 1990·Immunology Letters·T CommesB Klein
May 1, 1993·Annals of Hematology·M H van OersH M Lokhorst
Mar 1, 1992·Calcified Tissue International·S C Manolagas, R L Jilka
Jan 1, 1994·Journal of Neuro-oncology·R YamanakaS Okoshi
Jun 1, 1994·Journal of the American Geriatrics Society·M Gautier, H J Cohen
Sep 26, 2014·PloS One·Jérémie GaudichonBrigitte Sola
Mar 23, 2004·Biochemical and Biophysical Research Communications·Hélène LiboubanDaniel Chappard
Jul 4, 2012·Reumatología clinica·Lorena Alvarez-RodríguezVíctor Manuel Martínez-Taboada
Mar 9, 2004·Blood Cells, Molecules & Diseases·C Pellat-Deceunynck, R Bataille
Sep 13, 2016·International Journal of Molecular Sciences·Ensaf M Al-HujailyJeffrey A Medin
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Jacalyn Rosenblatt, David Avigan
Sep 29, 2005·Biochemical and Biophysical Research Communications·Naohiro TsuyamaHideaki Ishikawa
Feb 1, 1994·Journal of Neurosurgery·M D PartingtonB W Scheithauer

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