The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction

Biological Trace Element Research
Sanjali VermaPitchai Balakumar

Abstract

The present study has been designed to investigate the effect of benfotiamine, a thiamine derivative, in sodium arsenite-induced vascular endothelial dysfunction (VED) in rats. Sodium arsenite (1.5 mg(-1) kg(-1) day(-1) i.p., 2 weeks) was administered in rats to produce VED. The development of VED was assessed by employing isolated aortic ring preparation and estimating the serum and aortic concentrations of nitrite/nitrate. Further, the integrity of vascular endothelium in thoracic aorta was assessed by scanning electron microscopy. Moreover, the oxidative stress was assessed by estimating serum thiobarbituric acid reactive substances (TBARS) and aortic superoxide anion generation. The administration of sodium arsenite markedly produced VED by attenuating acetylcholine-induced endothelium-dependent relaxation, decreasing serum and aortic concentrations of nitrite/nitrate, and impairing the integrity of vascular endothelium. Further, sodium arsenite produced oxidative stress by increasing serum TBARS and aortic superoxide generation. The treatment with benfotiamine (25, 50, and 100 mg(-1) kg(-1) day(-1) p.o.) or atorvastatin (30 mg(-1) kg(-1) day(-1) p.o., a standard agent) prevented sodium arsenite-induced VED and oxidative st...Continue Reading

References

Jan 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L J Ignarro
Jan 1, 1994·Epidemiologic Reviews·R R EngelA H Smith
Jul 9, 1998·Molecular and Cellular Biochemistry·S Mittra, M Singh
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K R SmithA Barchowsky
Jun 19, 2002·Analytical Biochemistry·K V H SastryG S Rao
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Aug 21, 2003·Environmental Health Perspectives·Meei-Maan WuTe-Chang Lee
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John C K LaiUNKNOWN Heart Stroke Foundation of British Columbia and Yukon, Program Project Grant Investigators
Feb 28, 2004·Methods and Findings in Experimental and Clinical Pharmacology·M A IbrahimS Ueda
Nov 3, 2004·Toxicology and Applied Pharmacology·Melisa BundersonHoward D Beall
Oct 1, 2005·Journal of Human Hypertension·C Giansante, N Fiotti
Oct 22, 2005·Toxicology and Applied Pharmacology·Tsui-Chun TsouLouis W Chang
Mar 1, 2006·Cardiovascular Diabetology·Ricardo J EsperRogelio A Machado
Apr 6, 2006·Clinical Medicine & Research·Zhihong Yang, Xiu-Fen Ming
Jul 15, 2006·Molecular and Cellular Biochemistry·Dhvanit I Shah, Manjeet Singh
Nov 18, 2006·Fundamental & Clinical Pharmacology·Dhvanit I Shah, Manjeet Singh
Jan 24, 2007·International Journal of Cardiology·Dhvanit I Shah, Manjeet Singh
Feb 28, 2007·Acta Clinica Belgica·F Desjardins, J L Balligand
Aug 10, 2007·Current Diabetes Reports·Subramaniam Pennathur, Jay W Heinecke
Oct 28, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarManjeet Singh
Nov 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Christopher StatesAaron Barchowsky

❮ Previous
Next ❯

Citations

Sep 15, 2014·Toxicology and Applied Pharmacology·Thengumpallil Sasindran SarathSouvendra Nath Sarkar
Jul 25, 2014·Toxicology and Applied Pharmacology·Manickam KesavanSouvendra Nath Sarkar
Aug 6, 2011·Neurotoxicology and Teratology·Judith I HillsCarl L Keen
Sep 22, 2015·Frontiers in Cellular Neuroscience·Iva BozicIrena Lavrnja
Jun 17, 2015·Chemico-biological Interactions·Prashantkumar WagheSouvendra Nath Sarkar
Mar 20, 2015·The Journal of Pharmacology and Experimental Therapeutics·David C Ellinsworth
Jan 8, 2013·Molecular and Cellular Biochemistry·João Soeiro TeodoroCarlos Marques Palmeira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.