The definition of a neoplasm

Medical Hypotheses
M D Vincent

Abstract

No satisfactory definition of a neoplasm exists. Current criteria are shown to be invalid for strictly definitional purposes. Difficulties relate in part to the difference between descriptions and explanations, and also to the status of definitional "truths". Definitions function to assist recognition, convey meaning and highlight the essence of what requires further explanation. Existing deficiencies and the provision of an adequate alternative are therefore matters of interdisciplinary importance with broad ramifications, particularly for the design of rational therapy. A new definition is proposed which, while saying as much as can be said, is conservative. Criticism of its logical base is anticipated and countered; two possible problems cases are admitted and discussed.

References

Jan 1, 1979·Biochemical Pharmacology·H WaldW Czaczkes
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J E de Larco, G J Todaro
Aug 18, 1977·Nature·T Kajii, K Ohama
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K Illmensee, B Mintz
Aug 1, 1967·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S B Refsum, P Berdal
Jul 25, 1969·Science·R G McKinnellD D Labat
Aug 1, 1967·Cancer·P C Dyke, D A Mulkey
Nov 1, 1967·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O H Iversen
Jan 1, 1983·Annual Review of Biochemistry·J M Bishop
Oct 9, 1980·The New England Journal of Medicine·M B Sporn, G J Todaro

Citations

Jan 12, 2010·Evolution; International Journal of Organic Evolution·Mark Vincent

Related Concepts

Metazoa
Neoplastic Cell Transformation
Malignant Neoplasms
Neoplasms, Experimental

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.