PMID: 6160095Jul 1, 1980Paper

The definition of a new Ia antigenic specificity using the B6.C-H-2bml2 I-region mutant strain

Immunogenetics
G M MorganR W Melvold

Abstract

A new Ia specificity has been defined using the IA-subregion mutant B6.C-H-2bm12. The immunization to produce the antiserum was bml2 antiA.BY, as all other immunizations, such as bml2 anti-C57BL/6, failed to produce antibody. By selecting strains of C57BL origin for testing, it was shown that, (a) the serum was only weakly cytotoxic but gave substantial reactions using a rosetting assay; (b) the antibody reacted with B cells and not T cells; (c) strains of the b,d,p and q H-2 haplotypes were positive, whereas f,k,r and s were negative; (d) absorption studies demonstrated only a single specificity to be present and by testing recombinant strains, the reaction mapped to the IA subregion; (e) SDS-PAGE demonstrated that the antiserum reacted with a molecule of MW approximately 33,000. Preliminary studies indicate this new specificity, present on C57BL/6 and lost from bml2, is present on the same molecule as other I-A specificities.

References

Dec 1, 1979·The Journal of Experimental Medicine·I F McKenzieH I Kohn
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·P Lake, N A Mitchison
Jan 1, 1978·Journal of Immunological Methods·C R Parish, I F McKenzie
Jul 1, 1980·Immunogenetics·I F McKenzieR W Melvold
Dec 1, 1978·Immunogenetics·H I KohnD C Shreffler

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Citations

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y TseT H Hansen
Aug 1, 1982·The Journal of Experimental Medicine·H Y LeiC Waltenbaugh
Jan 1, 1983·Immunogenetics·L R PeaseS G Nathenson
Aug 1, 1982·Journal of Immunogenetics·M Michaelides, I F McKenzie
Jan 1, 1980·Immunogenetics·G M MorganD W Bailey
Mar 1, 1982·European Journal of Immunology·M S SandrinG J Hämmerling

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