The definition of left bundle branch block influences the response to cardiac resynchronization therapy

International Journal of Cardiology
Maria Luce CaputoAngelo Auricchio

Abstract

CRT has been proven to achieve most benefit in patients with left bundle branch block morphology (LBBB). However, ECG criteria to define LBBB significantly differ from each other. Objective of the study was to evaluate the impact of different ECG criteria for LBBB definition on survival, hospitalization for heart failure and reverse remodelling in patients who received cardiac resynchronization therapy (CRT). Three-hundred-sixteen consecutive patients were included in the analysis. Six different classifications were assessed in baseline ECGs of patients who received a CRT device: a QRS duration of ≥150 ms and LBBB according to AHA/ACC/HRS, ESC 2006, ESC 2009, ESC 2013 and the classification proposed by Strauss and colleagues. In univariate analysis, the ESC 2009 and 2013 and the Strauss classifications were significantly associated with a reduction in cumulative probability for heart failure (HF) and mortality (HR 0.60, 95%CI 0.42-0.86, HR 0.61, 95% CI 0.43-0.87 and HR 0.57, 95% CI 0.40-0.80, respectively). In multivariate analysis, the association with the combined endpoint was confirmed only for ESC 2009 and 2013 classifications and for Strauss. Moreover, the cumulative probability of all-cause death and HF hospitalizations w...Continue Reading

Citations

Feb 2, 2019·Circulation·Gaurav A UpadhyayRoderick Tung
May 17, 2019·Annals of Medicine·Marc StrikPierre Bordachar
Nov 28, 2019·Pacing and Clinical Electrophysiology : PACE·Zhixin JiangQijun Shan
Feb 26, 2019·PloS One·Alba Martín-Yebra, Juan Pablo Martínez
Jan 8, 2020·Journal of Cardiovascular Electrophysiology·Anaïs GautheyJean-Benoit le Polain de Waroux
Dec 22, 2020·Journal of Cardiovascular Electrophysiology·Ahran D ArnoldZachary I Whinnett
May 1, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S CalleJ De Pooter
Aug 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael GliksonKlaus K Witte
Aug 30, 2021·European Heart Journal·Michael GliksonUNKNOWN ESC Scientific Document Group

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