The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis

Oncogene
Alan J Davidson, L I Zon

Abstract

Progressive advances using zebrafish as a model organism have provided hematologists with an additional genetic system to study blood cell formation and hematological malignancies. Despite extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved. As a result, most (if not all) of the critical hematopoietic transcription factor genes identified in mammals have orthologues in zebrafish. As in other vertebrates, all of the teleost blood lineages are believed to originate from a pool of pluripotent, self-renewing hematopoietic stem cells. Here, we provide a detailed review of the timing, anatomical location, and transcriptional regulation of zebrafish 'primitive' and 'definitive' hematopoiesis as well as discuss a model of T-cell leukemia and recent advances in blood cell transplantation. Given that many of the regulatory genes that control embryonic hematopoiesis have been implicated in oncogenic pathways in adults, an understanding of blood cell ontogeny is likely to provide insights into the pathophysiology of human leukemias.

References

Jan 1, 1979·Developmental and Comparative Immunology·A Zapata
Nov 15, 1989·American Journal of Ophthalmology·A S KimmelK K Wells
Aug 1, 1985·Journal of Applied Toxicology : JAT·W E HawkinsW W Walker
Jun 15, 1973·Experientia·J P VoetsE De Maerteleire
Dec 1, 1984·Archives of Sexual Behavior·M FlemingB MacGowan
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·H W DetrichL I Zon
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·L RobbC G Begley
Jul 29, 1994·Cell·R Krumlauf
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·V E Valge-ArcherT H Rabbitts
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G BrecherE P Cronkite
Jan 1, 1996·British Journal of Haematology·D J Hill, A F Rowley
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q WangN A Speck
May 15, 1997·Oncogene·K ChlichliaK Khazaie
Feb 1, 1997·Molecular Human Reproduction·B Favier, P Dollé
Jun 20, 1998·Mechanisms of Development·R ToyamaI B Dawid
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J R JessenS Lin
Jun 2, 1998·Development Genes and Evolution·I RuvinskyR K Ho
Jul 22, 1998·The EMBO Journal·M GeringA R Green
Nov 7, 1998·Nature Genetics·H WangS Lin
Apr 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C E WillettA G Zapata
Dec 22, 1999·British Journal of Haematology·P JagadeeswaranD Troyer
Aug 31, 2000·Developmental Biology·M C Lane, M D Sheets
Apr 20, 2001·Genesis : the Journal of Genetics and Development·J R JessenS Lin
May 30, 2001·Trends in Immunology·N S TredeL I Zon
Jul 27, 2001·Blood·C M BennettA T Look
Aug 24, 2001·Developmental Biology·I Muñoz-Sanjuán, A H-Brivanlou
Sep 6, 2001·Blood·A C OatesL I Zon

❮ Previous
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Citations

Mar 15, 2006·Development Genes and Evolution·Benjamin M HoganGraham J Lieschke
Mar 6, 2010·Nature Protocols·Igor Mizgirev, Sergei Revskoy
Apr 27, 2013·Nature Reviews. Immunology·Wilson K Clements, David Traver
Aug 5, 2006·Cell Death and Differentiation·P M EimonA Ashkenazi
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cristian Soza-RiedThomas Boehm
Sep 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph S Lipsick
Jan 27, 2010·Development, Growth & Differentiation·Miki TakeuchiMakoto Kobayashi
Mar 23, 2006·Infection and Immunity·Astrid M van der SarAnnemarie H Meijer
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Volker Hartenstein
Aug 27, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li-Ming ChenWalter F Boron
Jun 21, 2007·Blood·Noëlle Paffett-LugassyLeonard I Zon
Jun 5, 2007·Blood·Alvin C H MaAnskar Y H Leung
Sep 1, 2007·Blood·Lisa J McReynoldsTodd Evans
Feb 6, 2008·Blood·Tomomasa YokomizoSatoru Takahashi
Jan 10, 2008·Blood·Duncan Carradice, Graham J Lieschke
Apr 23, 2010·Blood·Jill L O de JongLeonard I Zon
Aug 2, 2011·Veterinary Research·Davinia Morera, Simon A MacKenzie
May 5, 2007·BMC Developmental Biology·Chris HallPhil Crosier
Jan 21, 2011·Journal of Leukocyte Biology·Sa Kan Yoo, Anna Huttenlocher
Jun 29, 2011·Disease Models & Mechanisms·Lili Jing, Leonard I Zon
Jan 26, 2013·PLoS Genetics·Catarina M HenriquesMiguel Godinho Ferreira
Dec 2, 2011·PloS One·Ning MaWenqing Zhang
Jul 5, 2012·PloS One·Karine F Ferri-LagneauTinchung Leung
Sep 8, 2011·Journal of Visualized Experiments : JoVE·Gary F GerlachRebecca A Wingert
Mar 7, 2014·Journal of Hematology & Oncology·Zhi-Wei DongYong Zhou
May 23, 2014·Proceedings. Biological Sciences·Cayleih E RobertsonNicholas J Bernier

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