Nov 19, 2019

The degraded polysaccharide from Pyropia haitanensis represses amyloid beta peptide-induced neurotoxicity and memory in vivo

International Journal of Biological Macromolecules
Zhongshan ZhangGenxiang Mao

Abstract

An antioxidant polysaccharide, porphyran, from red algae Pyropia haitanensis, is introduced as a protective agent against neurotoxicity-induced amyloid β peptide (Aβ) of Alzheimer's disease (AD) mice. Then the activity of acetylcholinesterase (AChE) and choline acetyltransferase (CHAT) in the cortical and hippocampal tissue were examined by colorimetric method. Results showed that porphyran significantly ameliorated the learning and memory impairment induced by Aβ1-40. Biochemical analysis showed that porphyran increased ChAT activity and decreased AChE activity in the cortical and hippocampal tissue. The mechanism may be related with the increase of cerebral acetylcholine content. Porphyran has a potential of developing anti-aging drug.

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Mentioned in this Paper

In Vivo
Memory Impairment
Brain
Antioxidants
ACHE
Alzheimer's Disease
Pyropia haitanensis
Pharmacologic Substance
Choline O-Acetyltransferase
Acetylcholinesterase Activity

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