The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Thomas StrowitzkiHelena von Eye Corleta

Abstract

PCOS (polycystic ovarian syndrome) is a clinically heterogeneous endocrine disorder which affects up to 4-10% of women of reproductive age. A standardized definition is still difficult because of a huge variety of different phenotypes. The aim of this study was to evaluate possible correlations between the degree of cycle irregularity and the grade of endocrine and metabolic abnormalities. A cross-sectional study was carried out. Hyperandrogenic and/or hirsute women with regular menstrual cycles and polycystic ovaries on ultrasound (PCOS eumenorr, n=45), PCOS patients with oligomenorrhea (PCOS oligo, n=42) and PCOS patients with amenorrhea (PCOS amenorr, n=31) were recruited from the Department of Gynecological Endocrinology and Reproductive Medicine of the Women's University Hospital Heidelberg (Heidelberg, Germany). Normocyclic patients demonstrated significantly better metabolic parameters (BMI, fasting insulin, HOMA-IR) than patients with oligo/amenorrhea. Hormonal parameters (LH, FSH, FAI and testosterone) were significantly different between patients with different menstrual patterns and patients with regular cycles. Determining the degree of cycle irregularity as a simple clinical parameter might be a valuable instrument...Continue Reading

References

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Apr 12, 2007·Reproductive Biomedicine Online·Franz Geisthövel, Thomas Rabe

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Citations

Apr 13, 2011·Journal of Assisted Reproduction and Genetics·Sedigheh GhandiMohammad Hossein Sojoodi Moghaddam
Dec 6, 2011·American Journal of Epidemiology·Xiaobi HuangMichael R Elliott
Jan 17, 2012·Journal of Ovarian Research·Anita M PimentelHelena Ve Corleta
Nov 26, 2014·European Journal of Endocrinology·Simona GaberščekElisabeth Lerchbaum
Sep 27, 2014·Journal of Pediatric and Adolescent Gynecology·Isabel Cristina da Silva BouzasClaudia Braga
Jul 7, 2011·Journal of Ayurveda and Integrative Medicine·Radha MaharjanLaxmipriya Nampoothiri
Aug 21, 2013·Metabolism: Clinical and Experimental·Charles J GlueckJessica G Woo
May 10, 2011·Fertility and Sterility·John A MorrisonDavis Stroop
Jul 16, 2014·Taiwanese Journal of Obstetrics & Gynecology·Szu-Yu ShenChun-Sen Hsu
May 15, 2013·Clinical Endocrinology·Jee-Young OhHye Jin Lee
Jul 28, 2013·Journal of Ovarian Research·Anita Mylius PimentelHelena von Eye Corleta
Dec 20, 2016·PloS One·Marzieh Rostami DovomFereidoun Azizi
Apr 20, 2018·Frontiers in Endocrinology·Konstantinos Tziomalos, Konstantinos Dinas
Feb 23, 2021·International Journal of Endocrinology and Metabolism·Marzieh Saei Ghare NazFahimeh Ramezani Tehrani

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