PMID: 8614569Nov 17, 1995Paper

The degree of protection provided to neuronal cells by a pre-conditioning stress correlates with the amount of heat shock protein 70 it induces and not with the similarity of the subsequent stress

Neuroscience Letters
V AminDavid S Latchman

Abstract

A mild thermal stress protects primary cultures of dorsal root ganglion (DRG) neurons against a subsequent lethal heat stress as well as to a lesser extent against a subsequent lethal ischaemia. In contrast, a mild ischaemic stress protects DRG neurons only against a subsequent severe thermal stress and not against severe ischaemia. A greater induction of heat shock protein (hsp) synthesis was observed in these cells following mild temperature stress compared to mild ischaemia. This suggests that the protective effect observed is dependent on hsp synthesis resulting in the observed cross-protective effect and does not involve a particular pre-stress specifically protecting against a subsequent, more severe application of the same stress. Moreover, a particular level of hsp induction produces a better protective effect against lethal heat stress than against lethal ischaemia.

References

Feb 1, 1992·Journal of Molecular and Cellular Cardiology·D M Yellon, D S Latchman
Dec 1, 1991·Neuron·G RordorfJ V Bonventre
Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
Sep 30, 1988·Science·M F BarbeW J Welch
Nov 15, 1984·International Journal of Cancer. Journal International Du Cancer·U FerriniP G Natali
Oct 15, 1982·Biochemical and Biophysical Research Communications·J PlessetC S McLaughlin
Feb 25, 1980·Journal of Molecular Biology·S Lindquist

❮ Previous
Next ❯

Citations

May 5, 2005·Neurobiology of Aging·Rachel L GalliJames A Joseph
Feb 20, 2003·The Journal of Surgical Research·Amit BadhwarRichard F Potter
Dec 1, 1996·Brain Research. Molecular Brain Research·M J WagstaffJ S de Belleroche
Feb 25, 2000·Brain Research. Molecular Brain Research·D A Bechtold, I R Brown
Mar 7, 1997·Neuroscience Letters·L Xu, R G Giffard
Jun 30, 2006·Experimental Neurology·J KrishnanL Van Den Bosch
Oct 31, 2006·The American Journal of Pathology·Hae-June LeeYun-Sil Lee
Jul 29, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D S Latchman
Aug 23, 2001·Medical Hypotheses·M F McCarty
May 26, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E A PessoaN Schor
Nov 26, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Agata OrzechowskaPiotr Gałecki
Mar 30, 2001·The Journal of Biological Chemistry·N R MadamanchiM S Runge
Feb 13, 1999·The Journal of Biological Chemistry·M J WagstaffD S Latchman
Aug 5, 1998·The American Journal of Physiology·S PudupakkamR F Potter
Jul 16, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lesley ChengPhillip Nagley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.