The degrees of hepatocyte cytoplasmic expression of hepatitis B core antigen correlate with histologic activity of liver disease in the young patients with chronic hepatitis B infection.

Journal of Korean Medical Science
Tae Hyeon KimHaak Cheul Kim

Abstract

Subcellular localizaton of HBcAg have been found to be related to the activity of liver disease and HBV replication. The aim of this study was to determine whether the degree of expression of HBcAg in the hepatocyte nucleus and cytoplasm reflects the level of viral replication and histological activity in chronic HBV infection. A total of 102 patients with biopsy proven chronic hepatitis B were included. There was a highly significant correlation between the levels of HBV DNA in serum and the degree of expression of HBcAg in the nucleus for HBeAg-positive(p=0.000) and negative patients(p=0.04). There was a highly significant, correlation between the degrees of expression of HBcAg in hepatocyte cytoplasm and histologic activities (p<0.01) for HBeAg-positive patients. The degrees of expression of HBcAg in the hepatocyte cytoplasm correlated positively with the lobular activities (p<0.01), but not correlated with the portal activity and fibrosis for HBeAg-negative patients. In conclusion, in the young patients with chronic B viral hepatitis, the degree of expression of HBcAg in the hepatocyte nucleus may affect viral load, and the degree of expression of HBcAg in the hepatocyte cytoplasm may affect histologic activities of liver d...Continue Reading

References

Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J HadziyannisD A Shafritz
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
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May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Shih HsuYun-Fan Liaw

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Citations

Nov 6, 2009·The Journal of General Virology·Benedikte SerruysPeter Vanlandschoot
Apr 17, 2016·Journal of Hepatology·Marie-Lise BlondotMichael Kann
Jan 25, 2017·Viruses·Lara Gallucci, Michael Kann
Jul 27, 2010·European Journal of Clinical Investigation·Peter StärkelYves Horsmans
Mar 30, 2016·World Journal of Gastroenterology : WJG·Parham SafaieDaryl T Y Lau
Jan 1, 2015·Euroasian Journal of Hepato-gastroenterology·Ruksana RaihanJulio Cesar Aguilar
May 7, 2021·The Journal of Veterinary Medical Science·Jun LiYu-Zhang Wu

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Methods Mentioned

BETA
biopsy
biopsies

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