PMID: 9168271May 1, 1997Paper

The delayed-conditional-discrimination task improves measurement of working memory in rats

Neuroscience and Biobehavioral Reviews
A H Herremans, T H Hijzen

Abstract

The validity of delayed-matching-to-sample (DMTS) and related tasks executed in skinner boxes as an animal model for human working memory (WM) is confounded by the occurrence of mediating behaviour during delays. True matching, a supplementary task during delays and response similarity are ways to deal with this problem. However, until now rats have not been able to learn a true matching task in Skinner boxes and introduction of a supplementary task during delays does not sufficiently prevent mediating behaviour. Response similarity, on the other hand, effectively prevents the use of mediating behaviour by reducing the discriminative value of the behaviour during delays. Furthermore, it is argued that the interpretation of drug effects is confounded by baseline performance and mediating behaviour. It is shown that high baseline levels and high amounts of mediating behaviour can induce delay dependent drug effects, suggesting a specific effect on WM. We therefore assert that examination of delay-dependency of a drug effect alone is not sufficient to claim specific effects of a drug on WM. The delayed-conditional-discrimination (DCD) task uses response similarity to effectively reduce mediating behavior and does not generate high...Continue Reading

References

Apr 18, 1991·Behavioural Brain Research·N M RupniakS D Iversen
Aug 29, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G MorrisS P Butcher
Jun 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·B SahakianD Warburton
Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Oct 1, 1967·Psychological Bulletin·E H Cooper, A J Pantle
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Mishkin
Jul 30, 1982·Science·R T BartusA S Lippa
Jan 1, 1981·Experimental Brain Research·D S Olton, W A Feustle
Jul 1, 1980·Journal of Experimental Psychology. Animal Behavior Processes·W A Roberts
Jun 1, 1995·Behavioral Neuroscience·A H HerremansJ L Slangen
Nov 1, 1994·Journal of Neuroscience Methods·A Sahgal, T Steckler
Oct 30, 1987·Science·M Gallagher

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Citations

Feb 22, 2011·Psychopharmacology·Inge Klinkenberg, Arjan Blokland
Jul 24, 2015·Learning & Behavior·Aaron P SmithThomas R Zentall
Dec 18, 2013·Behavioural Brain Research·Elsa Y PioliJoseph P Garner
Jul 15, 2015·Behavioural Processes·Thomas R Zentall, Aaron P Smith
Apr 28, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rodolfo MazzonciniMirella Ruggeri
Apr 23, 2008·Current Protocols in Neuroscience·Susan B Powell, Mark A Geyer

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