The delayed depolarization in rat cutaneous afferent axons is reduced following nerve transection and ligation, but not crush: implications for injury-induced axonal Na+ channel reorganization

Muscle & Nerve
J SakaiK Hashi

Abstract

Two distinct populations of Na+ channels (kinetically fast and slow) are present on the cell bodies and axons of cutaneous afferent neurons; the fast current is increased and the slow current reduced in amplitude following nerve injury. The present study was undertaken to determine if similar changes occur on the axons of these neurons following peripheral nerve injury. The compound action potentials from rat sural nerves were recorded in a sucrose gap chamber. Following application of 4-aminopyridine, a prominent and well-characterized depolarization (the delayed depolarization) followed the action potential. This potential, only present on cutaneous afferent axons, has been correlated with activation of a slow Na+ current. The delayed depolarization was reduced after nerve transection. The refractory period of transmission of the action potential was shortened in the transected nerves, but that of the delayed depolarization was prolonged. The changes were largest when the sural nerve was cut and ligated [control: 38.1 +/- 1.7% (n = 5); injury: 24.5 +/- 2.8% (n = 5), P < 0.05], which prevented reconnection to its peripheral target. When the nerve was crushed and allowed to reestablish peripheral target connections, the delayed...Continue Reading

References

Jan 1, 1990·Progress in Neurobiology·M J Titmus, D S Faber
Dec 1, 1988·Journal of Neurophysiology·D L EngS G Waxman
Jun 1, 1988·Experimental Neurology·W S KingeryJ D Kocsis
Oct 1, 1982·Muscle & Nerve·J M Peyronnard, L Charron
May 1, 1994·Journal of Neurophysiology·O HonmouJ D Kocsis
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Dib-HajjS G Waxman

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Citations

Oct 11, 2002·IEEE Transactions on Bio-medical Engineering·Christopher J Poletto, Clayton L Van Doren
Oct 28, 2006·European Journal of Pharmacology·Mustafa GuvenFiliz Koc

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