The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat

Environmental Research
G LasfarguesD Lison

Abstract

Epidemiological and clinical studies suggest that inhalation of cobalt metal dust (Co) mixed with tungsten carbide particles (WC), but not of cobalt dust alone, may cause interstitial pulmonary lesions (hard metal disease). In previous experimental studies in the rat, we have demonstrated the greater acute pulmonary toxicity of a WC-Co mixture compared to Co or WC alone. The present study was undertaken to compare in the same animal model the delayed lung response after intratracheal administration of Co or WC-Co particles (cobalt particle 6.3 wt%). The responses were also compared with those obtained after treatment with arsenic trioxide and crystalline silica used a reference materials producing an acute toxic insult and a progressive fibrogenic response, respectively. Cellular (total and differential counts) and biochemical parameters (LDH, N-acetyl-beta-D-glucosaminidase, total protein, albumin, fibronectin, and hyaluronic acid) were measured in bronchoalveolar lavage fluid following single and repeated intratracheal instillations. The results indicate that the delayed lung response observed after WC-Co is different from that after cobalt metal alone. A single intratracheal dose of WC-Co (1, 5, or 10 mg/100 g body wt) induc...Continue Reading

Citations

Jul 17, 2008·Journal of Exposure Science & Environmental Epidemiology·Aleksandr B StefaniakGregory A Day
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·C G LardotD F Lison
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Gabriella BergaminiPaola Melotti
Oct 27, 2006·Respiratory Research·Rachida LegssyerTeresinha Leal
Aug 10, 2000·Environmental Health Perspectives·P KelleherL S Newman
Jun 22, 1999·Toxicology and Applied Pharmacology·A RengasamyJ S Fedan
Aug 4, 2001·Toxicology and Applied Pharmacology·J S Fedan, D Cutler
Aug 8, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kenjiro KogaKazuhiro Shintani
Jan 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dominique LisonBice Fubini
Jan 25, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Rafael Futoshi MizutaniUbiratan Paula Santos
Dec 12, 2012·Inhalation Toxicology·Narayanan RajendranCarmen Venezia
Apr 5, 2008·Toxicology and Industrial Health·L Samuel KeithUNKNOWN Agency for Toxic Substances and Disease Registry
Sep 10, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kara MillerAlicia M Bolt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.