PMID: 11917060Mar 28, 2002Paper

The deletion polymorphism of the ACE gene is not an independent risk factor for renal scarring in children with vesico-ureteric reflux

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Jan DudleyMary McGraw

Abstract

The deletion (D) polymorphism of the gene encoding angiotensin-I converting enzyme has been implicated as a risk factor for progressive renal disease in several conditions. This study was designed to evaluate the association between homozygosity for the D allele and susceptibility to renal scarring in children with vesico-ureteric reflux (VUR). Two-hundred-and-six children with VUR (all grades) were recruited into the study. Patients were stratified into two groups according to the presence or absence of renal scarring. One-hundred-and-twelve patients (group 1) had evidence of renal scarring. Ninety-four children had no evidence of renal scarring (group 2). ACE genotypes were determined by polymerase chain reaction (PCR) amplification of genomic DNA samples. There was no association between the DD polymorphism and the presence of renal scarring. Genotype frequencies in group 1 were: II, 29; ID, 56; and DD, 27; and in group 2 were: II, 12; ID, 52; DD, 30 (P=0.21). Neither was there evidence supporting a 'dominant' D allele. There was no association between the DD genotype and the presence of proteinuria or reduced renal function (P>0.05). Hypertension was seen more frequently in those individuals with the DD genotype, compared w...Continue Reading

References

Mar 1, 1994·Pediatric Pathology·S A HinchliffeD van Velzen
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S OzenE Tuncbilek
Feb 7, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J DudleyM E McGraw

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Citations

Jul 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eleni SekerliMagdalini Gatzola
Dec 1, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marco ZaffanelloGiovanni Malerba
Mar 30, 2005·Srpski arhiv za celokupno lekarstvo·Dragana Karaklajić, Amira Peco-Antić
Jun 25, 2005·American Heart Journal·Mark P Donahue, Andrew S Allen
Feb 13, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rafael PardoSocorro Braga
Mar 8, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tian-Biao ZhouDan-Dan Peng

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