The Delta Opioid Receptor in Pain Control

Handbook of Experimental Pharmacology
Khaled Abdallah, Louis Gendron

Abstract

Nowadays, the delta opioid receptor (DOPr) represents a promising target for the treatment of chronic pain and emotional disorders. Despite the fact that they produce limited antinociceptive effects in healthy animals and in most acute pain models, DOPr agonists have shown efficacy in various chronic pain models. In this chapter, we review the progresses that have been made over the last decades in understanding the role played by DOPr in the control of pain. More specifically, the distribution of DOPr within the central nervous system and along pain pathways is presented. We also summarize the literature supporting a role for DOPr in acute, tonic, and chronic pain models, as well as the mechanisms regulating its activity under specific conditions. Finally, novel compounds that have make their way to clinical trials are discussed.

Citations

Mar 7, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tsung-Chih TsengShiang-Jong Tzeng
Apr 13, 2020·Journal of Cellular and Molecular Medicine·Hanieh Bagheri TudashkiGraciela Pineyro
Sep 12, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Meridith T RobinsAndrey E Ryabinin
May 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jade DegrandmaisonLouis Gendron
Oct 20, 2020·ACS Pharmacology & Translational Science·Ariful IslamThomas M Keck
Sep 25, 2021·Journal of Neuroscience Research·Jade DegrandmaisonLouis Gendron

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