PMID: 7021483Jan 1, 1981Paper

The demonstration, by immunofluorescence, of Legionella pneumophila organisms in human lung tissue embedded in epoxy resin

Histochemistry
A R Skinner, A Swann

Abstract

Legionella pneumophila serogroup 1 has been demonstrated by indirect immunofluorescence in human lung tissue fixed in 10% formal saline and embedded in epoxy resin. The organism was visualised using Rabbit serogroup 1 antibody and Sheep anti rabbit fluorescein conjugate. The fluorescent labelled organism was found distributed throughout the tissue with focal areas in alveolar spaces and also visualised by electron microscopy in the same tissue. This method therefore enables specific identification of the L. pneumophila organism with the antiserum and also affords the opportunity of studying the bacterium ultrastructurally in the same tissue.

References

Sep 1, 1978·Journal of Clinical Microbiology·W B CherryR E Weaver
Sep 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B P Lane, D L Europa

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Citations

Mar 9, 2004·Micron : the International Research and Review Journal for Microscopy·D D'AlessandroF Bianchi
Jan 1, 1985·Progress in Histochemistry and Cytochemistry·J A Litwin

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