PMID: 6973616Jun 1, 1981Paper

The demyelinating effect of corneal HSV infections in normal and nude (athymic) mice

Journal of the Neurological Sciences
J J Townsend

Abstract

Nude (athymic) mice and their immune competent Balb/c litter mates were infected with herpes simplex virus (HSV) type I on the scarified cornea. Seven to eight days after infection the trigeminal root entry zone was examined by light and electron microscopy. The immune competent Balb/c litter mates demonstrated marked central nervous system (CNS) demyelination when compared to the T cell-deficient animals who showed mild edematous change and minimal CNS demyelination ultrastructurally 7 days after infection. Viral titers were similar in both groups at this time. These studies further substantiate a role for the cell-mediated immune system in the CNS demyelination 1 week after corneal infection with HSV.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W CammerS Gordon
Apr 2, 1976·Science·H L Lipton, M C Dal Canto
May 1, 1978·Journal of Neuropathology and Experimental Neurology·J J Townsend, J R Baringer
Jun 1, 1972·The Journal of General Virology·T J HillA P Roome

❮ Previous
Next ❯

Citations

Jan 1, 1989·Acta Neuropathologica·D Soffer, J R Martin
Feb 1, 1982·Journal of the Neurological Sciences·K KristenssonE Lycke
Aug 1, 1983·Journal of the Neurological Sciences·K KristenssonE Lycke
Nov 9, 2002·The Journal of Infectious Diseases·James R LokensgardPhillip K Peterson
Dec 14, 2012·PloS One·Hege Nordem SjåstadJens Egeland
Sep 1, 1992·American Journal of Otolaryngology·T BergströmA Vahlne
Jun 1, 1986·The Japanese Journal of Psychiatry and Neurology·K HamanoE Farkas-Bargeton
Jan 1, 1988·Annals of the New York Academy of Sciences·L F KastrukoffS U Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.