The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kalyan V SrinivasSteven A Siegelbaum

Abstract

The impact of a given neuronal pathway depends on the number of synapses it makes with its postsynaptic target, the strength of each individual synapse, and the integrative properties of the postsynaptic dendrites. Here we explore the cellular and synaptic mechanisms responsible for the differential excitatory drive from the entorhinal cortical pathway onto mouse CA2 compared with CA1 pyramidal neurons (PNs). Although both types of neurons receive direct input from entorhinal cortex onto their distal dendrites, these inputs produce a 5- to 6-fold larger EPSP at the soma of CA2 compared with CA1 PNs, which is sufficient to drive action potential output from CA2 but not CA1. Experimental and computational approaches reveal that dendritic propagation is more efficient in CA2 than CA1 as a result of differences in dendritic morphology and dendritic expression of the hyperpolarization-activated cation current (Ih). Furthermore, there are three times as many cortical inputs onto CA2 compared with CA1 PN distal dendrites. Using a computational model, we demonstrate that the differences in dendritic properties of CA2 compared with CA1 PNs are necessary to enable the CA2 PNs to generate their characteristically large EPSPs in response t...Continue Reading

Citations

Jan 18, 2018·Cell and Tissue Research·Vincent RobertRebecca A Piskorowski
May 4, 2018·Hippocampus·Kenneth Kay, Loren M Frank
Feb 19, 2020·The Journal of General Physiology·Vincent RobertRebecca A Piskorowski
Jan 23, 2020·Journal of Neurophysiology·Arjun V MasurkarSteven A Siegelbaum
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Rocío Valle-BautistaAnayansi Molina-Hernández
Feb 14, 2019·Cell Reports·Ivan Fernandez-LamoLiset Menendez de la Prida
Aug 29, 2020·JAMA Psychiatry·UNKNOWN Writing Committee for the Attention-Deficit/Hyperactivity DisorderTomáš Paus
Mar 24, 2021·Brain Research Bulletin·Paula LunardiGrace S Pereira
Jul 23, 2021·Journal of Neurochemistry·Rafael Falcón-MoyaAntonio Rodríguez-Moreno

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