The dendritic spine story: an intriguing process of discovery

Frontiers in Neuroanatomy
Javier DeFelipe

Abstract

Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study of the nervous system, and will also explore the early interpretation of these elements. This discovery represents an interesting chapter in the history of neuroscience as it shows us that progress in the study of the structure of the nervous system is based not only on the emergence of new techniques but also on our ability to exploit the methods already available and correctly interpret their microscopic images.

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Citations

Aug 19, 2015·Frontiers in Neuroanatomy·Nicolas Heck, Ruth Benavides-Piccione
Apr 23, 2016·Biomolecules·Miguel MedinaJesús Avila
Jun 25, 2016·Frontiers in Psychiatry·Jan Tønnesen, U Valentin Nägerl
Feb 7, 2016·The Journal of Comparative Neurology·Ignacio LegueyJavier DeFelipe
Mar 13, 2017·Brain Structure & Function·Carolina Gonzalez-RianoCoral Barbas
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chiara Cirelli, Giulio Tononi
Mar 6, 2019·Frontiers in Neuroanatomy·Marina BentivoglioPaolo Mazzarello
Jan 20, 2017·Molecular Neurobiology·Eva Mª Pérez-VillegasJosé A Armengol
Nov 6, 2018·Cerebral Cortex·Paula Merino-SerraisAngel Cedazo-Minguez
Sep 29, 2020·Frontiers in Synaptic Neuroscience·Karen RungeAntoine de Chevigny
Dec 17, 2020·Brain : a Journal of Neurology·Marta Montero-CrespoLidia Blazquez-Llorca
Feb 14, 2021·Scientific Reports·Raul Loera-ValenciaPaula Merino-Serrais
Feb 16, 2021·Cellular and Molecular Life Sciences : CMLS·Elena IrolloOlimpia Meucci
May 11, 2021·Frontiers in Cell and Developmental Biology·Maria Schörnig, Elena Taverna

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Methods Mentioned

BETA
electron microscopy

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