The denervated stomach as an esophageal substitute is a contractile organ

Annals of Surgery
J M CollardP J Kestens

Abstract

To determine whether the denervated stomach as an esophageal substitute is an inert conduit or a contractile organ. The motor response of gastric transplants to deglutition suggests that the stomach pulled up to the neck acts as an inert organ. The gastric motility of 11 healthy volunteers and 33 patients having either a gastric tube (GT) (n = 10) or their whole stomach (WS) (n = 23) as esophageal replacement was studied with perfused catheters during the fasting state, after a meal, and after intravenous administration of erythromycin lactobionate. A motility index was established for each period of recording by dividing the sum of the areas under the curves of all contractions of >9 mmHg by the time of recording. Over years, the denervated stomach recovers more and more motor activity, even displaying a real phase 3 motor pattern in 6 of the 10 WS patients and 1 of the 7 GT patients with >3 years of follow-up. Erythromycin lactobionate generates a phase 3-like motor pattern regardless of the length of follow-up. Extrinsic denervation of the whole stomach does not significantly modify the fasting motility index established >3 years after surgery (+17% on average, p > 0.05), but it reduces that in the fed period by an average o...Continue Reading

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Citations

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May 3, 2011·Surgery Today·Hideyuki UbukataTakafumi Tabuchi
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Jul 1, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Tetsurou TerashimaKatsuyoshi Hatakeyama
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