PMID: 22569259DOI: 10.1016/j.febslet.2012.02.047May 10, 2012Paper
The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers
FEBS Letters
Sook-San WongJ M Mackenzie
Abstract
The dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E.
References
Jan 1, 1985·The American Journal of Tropical Medicine and Hygiene·E A HenchalW E Brandt
Feb 1, 1993·The Journal of General Virology·J M MurrayP J Wright
Oct 29, 1997·Journal of Virology·K StadlerF X Heinz
Dec 12, 1997·Journal of Virological Methods·T R KreilM M Eibl
Mar 31, 1998·The Journal of General Virology·R C GualanoA D Davidson
Mar 12, 1999·Journal of Virology·L CocquerelJ Dubuisson
Jun 11, 1999·Journal of Virology·M FlamandV Deubel
Mar 15, 2000·Journal of Molecular Biology·W P Russ, D M Engelman
Mar 15, 2002·Cell·Richard J KuhnJames H Strauss
Mar 22, 2002·Journal of Virology·Séverine Carrère-KremerJean Dubuisson
May 7, 2002·Journal of Virology·Ivo C LorenzAri Helenius
Dec 28, 2002·Journal of Virology·Anne Op De BeeckJean Dubuisson
Sep 19, 2003·The Journal of General Virology·Adeline CatteauPhilippe Desprès
Oct 31, 2003·Biochimie·Adeline CatteauPhilippe Desprès
Sep 3, 2004·Structure·Ying ZhangMichael G Rossmann
Oct 28, 2004·Journal of Virology·Anne Op De BeeckJean Dubuisson
Mar 29, 2008·Science·I-Mei YuJue Chen
Jun 25, 2008·Biochemical and Biophysical Research Communications·Xiaoqun DuanYongming Liu
Aug 21, 2009·Apoptosis : an International Journal on Programmed Cell Death·Magali BrabantEtienne Jacotot
Dec 8, 2009·Biochemical and Biophysical Research Communications·Fang GaoJun Li
Jan 26, 2011·Virology·Sook-San WongEric J Gowans
Jul 20, 2011·Virology·Jean-Baptiste BraultNathalie Pardigon
❮ Previous
Next ❯
Citations
May 30, 2015·The Journal of General Virology·Claire Scott, Stephen Griffin
Jul 31, 2014·Biochemistry·Henrique Nemésio, José Villalaín
Mar 1, 2015·Journal of Biomolecular Screening·Zachary D StolpRoland Wolkowicz
Sep 8, 2018·Frontiers in Immunology·Nagesh K Tripathi, Ambuj Shrivastava
Dec 11, 2019·Vaccines·Joshua BlightArturo Reyes-Sandoval
May 22, 2021·European Journal of Medicinal Chemistry·Akshatha H SManisha Singh
❮ Previous
Next ❯
Related Concepts
Related Feeds
Related Papers
Microbes and Infection
Zhaoni ChenRenbin Huang
The Journal of General Virology
Izabela A ZybertJolanda M Smit
Current Opinion in Virology
Theodore C Pierson, Michael S Diamond
The Journal of General Virology
Yann CiczoraJean Dubuisson
The Journal of Biological Chemistry
Qian ZhangShee-Mei Lok