The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia

Biological Psychiatry
David CotterIan Everall

Abstract

There is strong evidence for the presence of a deficit in cortical gamma aminobutyric acid (GABA) neurotransmission in schizophrenia. In this investigation we have used the calcium binding proteins (CBPs) parvalbumin (PV), calretinin (CR), and calbindin-D28K (CB) as markers of these neuronal populations, and have characterized their pattern and density in schizophrenia, bipolar disorder (BPD), and major depressive disorder (MDD). We examined the anterior cingulate cortex (ACC) in four groups of 15 brains each from subjects with schizophrenia, MDD, and BPD, and from control subjects. Using immunocytochemistry to identify these distinct neuronal populations, we quantified their areal density and spatial pattern organization. There were reductions in the density of CB-labeled neurons in layer 2 in schizophrenia (34%; p =.04) and BPD (33%; p =.05) compared with control subjects; however, after correction for multiple comparisons these findings no longer attained formal statistical significance. We observed no differences in the density of the neuronal populations labeled by CR or PV in any layer of the cortex in any disorder compared with control subjects. There was increased clustering among PV-labeled neurons in BPD compared with...Continue Reading

References

Jan 2, 1991·Neuroscience Letters·A D ShermanR Waziri
Nov 1, 1987·Archives of General Psychiatry·F M BenesC A Marotta
Jul 1, 1987·Archives of General Psychiatry·F M Benes, E D Bird
Jan 4, 1998·Cerebral Cortex·L S KrimerD R Weinberger
Jun 6, 2000·Biological Psychiatry·K A YoungD C German
Feb 13, 2001·Trends in Neurosciences·F M Benes, N Lange
May 1, 1989·The European Journal of Neuroscience·E. G. Jones, S. H. C. Hendry

❮ Previous
Next ❯

Citations

Dec 20, 2005·Experimental Brain Research·Chao Deng, Xu-Feng Huang
Dec 21, 2006·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischBernhard Bogerts
Apr 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Tomasz GosBernhard Bogerts
Feb 10, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Erick T TatroUNKNOWN HIV Neurobehavioral Research Center
Oct 6, 2007·Molecular Neurobiology·Gerhard Rammes, Rainer Rupprecht
May 11, 2005·Neuroscience Letters·Kyohei OtaniShigetoshi Kuroda
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paul A Tooney, Loris A Chahl
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenji IkedaKazuhiro Niizato
Jun 11, 2005·Schizophrenia Research·Lise RiouxSteven Edward Arnold
Mar 22, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aine T BehanDavid R Cotter
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
Oct 26, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Grazyna RajkowskaJose Javier Miguel-Hidalgo
Oct 4, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert J SchloesserHusseini K Manji
Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cheng Z WangKenneth M Johnson
Jul 12, 2012·Translational Psychiatry·N M WaltonM Matsumoto
Apr 15, 2009·Current Opinion in Psychiatry·Alex FornitoChristos Pantelis
Apr 3, 2009·The Journal of Clinical Investigation·Keri MartinowichHusseini K Manji
Mar 27, 2013·Molecular Psychiatry·A L Guillozet-BongaartsJ E Kleinman
Dec 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Phil Ok KohMichael S Lidow
Jan 24, 2012·AJNR. American Journal of Neuroradiology·L M Levy, A J Degnan
Feb 20, 2003·Schizophrenia Research·Peter DanosBernhard Bogerts
Dec 22, 2015·Journal of Chemical Neuroanatomy·John F SmileyAndrew J Dwork
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ahmad KhundakarAlan J Thomas
Jan 28, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rebecca E KaufmanMark H Pollack
Jun 10, 2008·Brain Research Reviews·Konstantinos N FountoulakisConstantin Bouras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.