The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation

Investigative Ophthalmology & Visual Science
Beatrice M TamOrson L Moritz

Abstract

To characterize the influence of light and vitamin A on retinal degeneration in an animal model of retinitis pigmentosa caused by the rhodopsin P23H mutation. Retinal degeneration was examined in transgenic Xenopus laevis expressing P23H rhodopsin, in which retinal degeneration is completely rescued by preventing light exposure. The sensitivity of this retinal degeneration to varying intensities, wavelengths, and durations of light exposure, and to vitamin A deprivation was characterized. Green light was the most effective inducer of retinal degeneration in this model. Retinal degeneration was induced by prolonged exposure to green light and was prevented by filters that block short wavelengths. Reducing the duration of light exposure prevented retinal degeneration, even when the light intensity was proportionally increased. Vitamin A deprivation also induced retinal degeneration associated with defects in P23H rhodopsin biosynthesis. Vitamin A deprivation did not cause retinal degeneration in nontransgenic animals. The mechanism of retinal degeneration in this animal model of RP involves the interaction of light with rhodopsin rather than with free chromophore or bleached rhodopsin. These results may explain the clinical benef...Continue Reading

Citations

Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Damian C LeeOrson L Moritz
Nov 12, 2013·Human Molecular Genetics·Sanae SakamiKrzysztof Palczewski
Apr 7, 2016·Cell Reports·Wei WangDouglas C Dean
May 27, 2015·Experimental Eye Research·Beatrice M TamOrson L Moritz
Jun 28, 2019·Investigative Ophthalmology & Visual Science·Harry O OrlansRobert E MacLaren
Mar 7, 2019·Investigative Ophthalmology & Visual Science·Ulisse BoccheroOrson L Moritz

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