PMID: 7941451Jun 1, 1994Paper

The dependence of the biological activity of metal complexes on the structural stability of the initial DNA

Voenno-medit︠s︡inskiĭ zhurnal
Iu P VaĭnbergE N Kaplina

Abstract

The authors have formulated the basic principles of the creation of metallo-constructions with DNA which possess biological activity. Thus, the interaction of metal and DNA during formation of metallo-construction must not destabilize the structure of initial DNA. The studies conducted by the authors prove the hypothesis of the working mechanism of these complexes: pronounced activity against viruses which contain DNA and RNA.

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