The depletion of substance P by diclofenac in the mouse

European Journal of Pharmacology
J PapworthD Willoughby

Abstract

Diclofenac in hyaluronan is analgesic and angiostatic. The depletion of substance P may be a common mechanism. Mice received diclofenac, diclofenac in hyaluronan, or saline i.v. for 5 days and snout substance P assessed: saline 2.80 +/- 0.23; 0.5 mg/kg diclofenac 2.03 +/- 0.20 (P < 0.05); diclofenac in hyaluronan 1.88 +/- 0.21 (P < 0.02); capsaicin 1.45 +/- 0.26 fmol/mg tissue (P < 0.005). Substance P recovered by 5 days (diclofenac in hyaluronan, capsaicin) and 24 h (diclofenac). Diclofenac may deplete substance P in analgesia, and hyaluronan prolong the depletion.

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Citations

May 18, 2010·Current Medical Research and Opinion·Tong J Gan
Jan 6, 2004·Cornea·Masakazu YamadaTeruo Nishida
Apr 15, 2004·Cell Motility and the Cytoskeleton·Lin-Yun LiuYan-Ai Mei
Jun 24, 2004·Canadian Journal of Physiology and Pharmacology·H F MirandaG Pinardi
Apr 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rika SuzukiEiichi Kumamoto

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