The depth of follicular extension in actinic keratosis correlates with the depth of invasion in squamous cell carcinoma: implication for clinical treatment

Journal of the European Academy of Dermatology and Venereology : JEADV
M T Fernández-FiguerasA Ariza

Abstract

Actinic keratosis (AK) may show extension down follicles, not only in cases with full-thickness epidermal atypia ('bowenoid' AK), but also in cases with atypia limited to the epidermal basalis. Previous studies have demonstrated that, in bowenoid AK, follicular extension is usually superficial, being limited to the upper follicular segment. Little is known about the depth of follicular involvement in cases of invasive squamous cell carcinoma of the skin (iSCC) arising from AK and the role of the follicle in iSCC pathogenesis. This study investigated the relationship between follicular extension of atypical keratinocytes in an AK and the development of iSCC from the follicular wall. The depth of follicular extension was correlated with the depth invasion of iSCC. Differences between the differentiated and classical pathways of iSCC were also examined. We performed a retrospective histologic review of 193 biopsy specimens of iSCC with an associated AK. We assessed the presence and depth of follicular extension of atypical keratinocytes in the AK, using tumour (Breslow) thickness and the follicular unit level (infundibular, isthmic and subisthmic), as well as iSCC being present directly adjacent to the follicular basalis. Follicul...Continue Reading

References

Jan 13, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·L H GoldbergJ D Schmidt
Dec 17, 2003·Journal of Cutaneous Pathology·Carlos Diaz-CascajoJesus Bastida-Inarrea
Sep 15, 2004·The American Journal of Dermatopathology·Philip E LeBoit
Dec 18, 2013·Nature Cell Biology·A C WhiteW E Lowry
Nov 28, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M T Fernández-FiguerasA Ariza
Dec 26, 2015·Journal of Lower Genital Tract Disease·Jacob BornsteinUNKNOWN ISSVD Terminology Committee
May 11, 2016·The Journal of Investigative Dermatology·William E LowryAndrew C White
Mar 7, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M T Fernandez Figueras

❮ Previous
Next ❯

Citations

May 29, 2020·Indian Journal of Dermatology, Venereology and Leprology·Eswari LoganathanYu-Hung Wu
Dec 15, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·T LugerC Traidl-Hoffmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.