The design and fabrication of supramolecular semiconductor nanowires formed by benzothienobenzothiophene (BTBT)-conjugated peptides

Nanoscale
Mohammad Aref KhalilyMustafa O Guler

Abstract

π-Conjugated small molecules based on a [1]benzothieno[3,2-b]benzothiophene (BTBT) unit are of great research interest in the development of solution-processable semiconducting materials owing to their excellent charge-transport characteristics. However, the BTBT π-core has yet to be demonstrated in the form of electro-active one-dimensional (1D) nanowires that are self-assembled in aqueous media for potential use in bioelectronics and tissue engineering. Here we report the design, synthesis, and self-assembly of benzothienobenzothiophene (BTBT)-peptide conjugates, the BTBT-peptide (BTBT-C3-COHN-Ahx-VVAGKK-Am) and the C8-BTBT-peptide (C8-BTBT-C3-COHN-Ahx-VVAGKK-Am), as β-sheet forming amphiphilic molecules, which self-assemble into highly uniform nanofibers in water with diameters of 11-13(±1) nm and micron-size lengths. Spectroscopic characterization studies demonstrate the J-type π-π interactions among the BTBT molecules within the hydrophobic core of the self-assembled nanofibers yielding an electrical conductivity as high as 6.0 × 10-6 S cm-1. The BTBT π-core is demonstrated, for the first time, in the formation of self-assembled peptide 1D nanostructures in aqueous media for potential use in tissue engineering, bioelectron...Continue Reading

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Citations

Sep 8, 2020·Chemistry : a European Journal·Bilal ÖzenHolger Frauenrath
Mar 30, 2021·ACS Biomaterials Science & Engineering·Sofia PeressottiRylie A Green
Mar 30, 2021·Materials Today. Bio·Ruslan Garifullin, Mustafa O Guler

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Methods Mentioned

BETA
atomic
transmission electron microscopy
acylation
NMR
circular
X-ray
atomic force microscopy
AFM

Software Mentioned

SASfit

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