The design and scale-up of spray dried particle delivery systems

Expert Opinion on Drug Delivery
Ali Al-KhattawiDavid Wilson

Abstract

The rising demand for pharmaceutical particles with tailored physicochemical properties has opened new markets for spray drying especially for solubility enhancement, improving inhalation medicines and stabilization of biopharmaceuticals. Despite this, the spray drying literature is scattered and often does not address the principles underpinning robust development of pharmaceuticals. It is therefore necessary to present clearer picture of the field and highlight the factors influencing particle design and scale-up. The review presents a systematic analysis of the trends in development of particle delivery systems using spray drying. This is followed by exploring the mechanisms governing particle formation in the process stages. Particle design factors including those of equipment configurations and feed/process attributes were highlighted. Finally, the review summarises the current industrial approaches for upscaling pharmaceutical spray drying. Spray drying provides the ability to design particles of the desired functionality. This greatly benefits the pharmaceutical sector especially as product specifications are becoming more encompassing and exacting. One of the biggest barriers to product translation remains one of scale-...Continue Reading

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Citations

May 7, 2019·Pharmaceutical Development and Technology·Sadegh Poozesh, Seid Mahdi Jafari
Mar 12, 2021·Environmental Science and Pollution Research International·Argyris Panagopoulos
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Mar 31, 2021·Annual Review of Chemical and Biomolecular Engineering·John M BaumannJoel D Wood
Jun 20, 2021·Comprehensive Reviews in Food Science and Food Safety·Maria Tereza Cratiú MoreiraAntônio Fernandes de Carvalho
Sep 26, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Justice ArcherJonathan Philip Reid

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