The design and scale-up of spray dried particle delivery systems

Expert Opinion on Drug Delivery
Ali Al-KhattawiDavid Wilson


The rising demand for pharmaceutical particles with tailored physicochemical properties has opened new markets for spray drying especially for solubility enhancement, improving inhalation medicines and stabilization of biopharmaceuticals. Despite this, the spray drying literature is scattered and often does not address the principles underpinning robust development of pharmaceuticals. It is therefore necessary to present clearer picture of the field and highlight the factors influencing particle design and scale-up. The review presents a systematic analysis of the trends in development of particle delivery systems using spray drying. This is followed by exploring the mechanisms governing particle formation in the process stages. Particle design factors including those of equipment configurations and feed/process attributes were highlighted. Finally, the review summarises the current industrial approaches for upscaling pharmaceutical spray drying. Spray drying provides the ability to design particles of the desired functionality. This greatly benefits the pharmaceutical sector especially as product specifications are becoming more encompassing and exacting. One of the biggest barriers to product translation remains one of scale-...Continue Reading


Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Jun 20, 1997·Science·D A EdwardsR Langer
Aug 1, 1997·Pharmaceutical Development and Technology·Y F MaaC C Hsu
Apr 1, 1999·Biotechnology and Bioengineering·Y F MaaC C Hsu
Jul 27, 1999·Journal of Microencapsulation·D F BainA Smith
Nov 17, 1999·Journal of Pharmaceutical Sciences·D J GreenhalghP York
Nov 26, 1999·Pharmaceutical Research·R VanbeverD A Edwards
Apr 6, 2000·Pharmaceutical Research·L A DellamaryJ G Weers
Jun 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fang Jing Wang, Chi Hwa Wang
Aug 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·N TsapisD A Edwards
Mar 28, 2003·Journal of Pharmaceutical Sciences·Jessica ElverssonUlla Elofsson
Sep 10, 2003·Journal of Colloid and Interface Science·Ferry IskandarKikuo Okuyama
Nov 19, 2003·Pharmaceutical Research·Daniel S KohaneRobert Langer
Jan 14, 2004·Journal of Microencapsulation·C KusonwiriyawongE Walter
Oct 19, 2004·International Journal of Pharmaceutics·Abdolhossien Rouholamini NajafabadiMorteza Rafiee-Tehrani
Dec 8, 2004·Pharmaceutical Development and Technology·Kristina MosénAnders Axelsson
Mar 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michael MauryGeoffrey Lee
Apr 20, 2005·Pharmaceutical Research·Julie A StraubHoward Bernstein
Jul 30, 2005·Journal of Pharmaceutical Sciences·Jessica Elversson, Anna Millqvist-Fureby
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A StraubHoward Bernstein
Nov 23, 2006·Journal of Microencapsulation·Henry NetteyMartin J D'Souza
Jul 10, 2007·Advanced Drug Delivery Reviews·Abu T M Serajuddin
Sep 8, 2007·Journal of Pharmaceutical Sciences·David Lechuga-BallesterosMei-Chang Kuo
Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Jan 17, 2008·Critical Reviews in Therapeutic Drug Carrier Systems·Peter C SevilleTristan P Learoyd
Apr 2, 2008·Pharmaceutical Development and Technology·Pia ThyboJesper Saederup Lindeløv
Jul 26, 2008·International Journal of Pharmaceutics·L X LiuT Howes
Nov 22, 2008·Journal of Food Science·U V Lay MaJ D Floros
May 21, 2009·Journal of Pharmaceutical Sciences·Hisham Al-ObaidiGraham Buckton
May 26, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lorraine M NolanAnne Marie Healy
Aug 5, 2009·Journal of Pharmaceutical Sciences·Niklas Sandler, David Wilson
Mar 18, 2010·Journal of Pharmaceutical Innovation·Dan E DobryRon A Beyerinck
May 14, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joshua J Neumiller, R Keith Campbell
Sep 13, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vishal M SonjeArvind K Bansal
Oct 11, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pierre LebrunPhilippe Hubert
Oct 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jian X WuJukka Rantanen

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