The design plan of kinesin motors

Annual Review of Cell and Developmental Biology
R D Vale, R J Fletterick

Abstract

The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.

References

Dec 1, 1992·The Journal of Cell Biology·H AizawaN Hirokawa
Feb 1, 1992·The Journal of Cell Biology·M de CuevasL S Goldstein
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J L CyrS T Brady
Nov 9, 1989·Nature·J HowardR D Vale
Jan 1, 1987·Annual Review of Cell Biology·R D Vale
Jun 1, 1994·The Journal of Cell Biology·S KondoN Hirokawa
Jan 1, 1995·Cell Motility and the Cytoskeleton·S RayK H Downing
Jul 20, 1995·Nature·A HoengerR A Milligan
Jul 1, 1995·Trends in Biochemical Sciences·C P Ponting
Sep 15, 1995·Journal of Molecular Biology·D J RashidJ M Scholey
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·E Meyhöfer, J Howard
Feb 23, 1995·Nature·S P GilbertK A Johnson
Mar 1, 1995·The Journal of Cell Biology·S Z Wang, R Adler
Aug 1, 1994·Biophysical Journal·A J HuntJ Howard
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D D Hackney
Jun 1, 1993·The Journal of Cell Biology·S RayJ Howard
Jan 1, 1993·Annual Review of Genetics·L S Goldstein
Jun 3, 1994·Cell·K Svoboda, S M Block
Nov 1, 1993·The Journal of Cell Biology·M M HeckL S Goldstein

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Citations

Apr 22, 1999·Microscopy Research and Technique·M ShirasuC E Walczak
Mar 4, 2000·The Anatomical Record·V Mountain, D A Compton
Oct 17, 2002·The Anatomical Record·Reid F Thompson, George M Langford
Dec 22, 1999·Journal of Structural Biology·Y HanK H Downing
Dec 21, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Tanja PetersJohanna Weiss
Nov 8, 2008·Biomedical Microdevices·Vivek VermaJeffrey M Catchmark
Mar 11, 2008·Plant Molecular Biology·Natalie JamesonShailesh Lal
May 10, 2005·Gene·G Luboshits, D Benayahu
Feb 19, 2000·Current Opinion in Cell Biology·E P Sablin
Feb 27, 1999·Current Opinion in Cell Biology·E Mandelkow, A Hoenger
Dec 26, 2001·Current Opinion in Structural Biology·E P Sablin, R J Fletterick
Jun 17, 2000·Trends in Cell Biology·B D Manning, M Snyder
Dec 24, 2002·Trends in Cell Biology·Eckhard Mandelkow, Eva-Maria Mandelkow
Jan 22, 2003·Trends in Cardiovascular Medicine·Yassemi Capetanaki
May 14, 2003·Fungal Genetics and Biology : FG & B·Conrad L SchochB Gillian Turgeon
Nov 17, 2001·Current Opinion in Pharmacology·K W WoodJ R Jackson
Oct 4, 2006·Biochemistry·Jared C CochranSusan P Gilbert
Aug 1, 2013·Journal of Medicinal Chemistry·Ambily Nath Indu Viswanath, Ae Nim Pae
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Michael Glotzer
Jul 23, 2013·Nature Structural & Molecular Biology·Benoît GigantMarcel Knossow
May 7, 1999·European Journal of Biochemistry·S SackE Mandelkow
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Braulio Gutiérrez-MedinaSteven M Block
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yao Liang Wong, Sarah E Rice
Sep 15, 2012·The Journal of Biological Chemistry·Chun Ju ChenSusan P Gilbert
May 13, 2003·The Journal of Biological Chemistry·Aouatef AbazaFabienne Pirollet
Jan 22, 2008·Assay and Drug Development Technologies·Richard A KlinghofferMichele A Cleary
Jan 19, 2000·Molecular Biology of the Cell·D J SharpJ M Scholey
Apr 6, 2000·Molecular Biology of the Cell·R P BrendzaW M Saxton
Aug 20, 2003·Molecular Biology of the Cell·Joseph G GindhartAline Nandlestadt
May 20, 2005·Molecular Biology of the Cell·Friederike BatheGuenther Woehlke
Oct 4, 2013·Molecular Biology of the Cell·Amit TuliMichael B Brenner

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Methods Mentioned

BETA
PCR
electron microscopy
motility
NMR

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