The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion

The Journal of Clinical Endocrinology and Metabolism
S TsagarakisN Thalassinos

Abstract

The role of desmopressin, alone or in combination with CRH, in the differential diagnosis between Cushing's disease (CD) and ectopic ACTH secretion (EAS) still remains uncertain. Based on existing data, the desmopressin test is regarded as an alternative to the CRH stimulation test and, when given in combination with CRH, it has been suggested to completely discriminate between patients with CD and EAS. However, assessment of these tests has been limited in only a small number of patients with EAS. Desmopressin is a relatively specific V2 vasopressin receptor (V2R) agonist. Although expression of V3 vasopressin receptor (V3R) is common in tumors with EAS, the expression of V2R has not been extensively investigated. In the present study, we report our findings of the desmopressin and the combined CRH-desmopressin test in a series of patients with CD and EAS; also, the expression of V2R and V3R was investigated in tumors with EAS by a RT-PCR method. We assessed a cohort of 31 patients with ACTH-dependent Cushing's syndrome, including 26 patients with CD and five cases with histologically confirmed EAS. To avoid bias of predetermined criteria, univariate curves of the receiver operating characteristics (ROC) were constructed by pl...Continue Reading

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Citations

Jan 27, 2009·Journal of Endocrinological Investigation·L VilarL A Casulari
Jun 20, 2012·Orphanet Journal of Rare Diseases·Frederic CastinettiThierry Brue
Nov 24, 2007·Pituitary·Blerina Kola, Ashley B Grossman
Mar 31, 2015·Endocrine Journal·Yoshihiro SekiguchiYukio Hirata
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarOscar D Bruno
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Nora Maria Elvira AlbigerFranco Mantero
Aug 13, 2005·Antonie van Leeuwenhoek·B Helen Jost, Stephen J Billington
Feb 24, 2018·European Journal of Endocrinology·Dimitra Argyro Vassiliadi, Stylianos Tsagarakis
Jun 11, 2021·Annals of Laboratory Medicine·Silvia PinelliFilippo Ceccato
Oct 27, 2021·Journal of Endocrinological Investigation·E FerranteC Scaroni

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