PMID: 6987494Jan 1, 1980Paper

The detection of carcinogen-induced sperm head abnormalities in mice

Mutation Research
J C Topham

Abstract

The (CBA X BALB/c(F1 male mouse is sensitive to the induction of sperm-head abnormalities after exposure to a range of chemical mutagens and carcinogens. 8 carcinogens including ethionine and diethyl stilboestrol were correctly identified. 23 non-carcinogens and compounds of unknown carcinogenicity including a range of 13 substituted anilines and methionine did not induce sperm-head abnormalities. 4-Aminophenol induced an increase in sperm-head abnormalities. The utility of the procedure for identifying genotoxic compounds is discussed.

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A J Wyrobek, W R Bruce
Feb 1, 1970·Biological Reviews of the Cambridge Philosophical Society·R A Beatty

❮ Previous
Next ❯

Citations

Nov 1, 1980·Archives of Toxicology·M Hofnung, N Weill
Jan 1, 1983·Mutation Research·A P Hugenholtz, W R Bruce
Sep 1, 1988·Mutation Research·I QuintoN Staiano
Oct 1, 1982·Mutation Research·M ZdzienickaM Pieńkowska
Dec 1, 1989·Mutation Research·I QuintoN Staiano
Jan 1, 1992·Mutation Research·G MathewM Abdul Rahiman
Jul 1, 1981·Mutation Research·L C GinsbergG Ficsor
May 30, 2001·Mutation Research·S Padmalatha Rai, K K Vijayalaxmi
Nov 24, 2001·Mutation Research·K NarayanaK P Seetharama Rao
Jul 1, 1987·Food Additives and Contaminants·R D Combes
Apr 1, 1993·Journal of Toxicology and Environmental Health·E Hemavathi, M A Rahiman
Apr 5, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Enver Kerem Dirican, Yusuf Kalender
Jan 1, 1986·Toxicology and Applied Pharmacology·D P EvensonR W Gesch
Jul 30, 2005·Drug and Chemical Toxicology·M S ShahabuddinK K Vijayalaxmi
Jan 1, 1987·Environmental Mutagenesis·P B Rastogi, R E Levin
Aug 9, 2007·Andrologia·G Gallegos-AvilaG Jaramillo-Rangel
Aug 15, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R SharmaS C Taneja
Jan 1, 1992·Cytometry·R M ZuckerK H Elstein
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·G FicsorL C Ginsberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.