The detection of pulmonary metastases by helical CT: a clinicopathologic study in dogs

Journal of Computer Assisted Tomography
D J WatersS A Heifetz

Abstract

We sought to determine the accuracy of helical CT in the detection of pulmonary metastases. Four anesthetized dogs with metastatic osteosarcoma underwent helical CT with a collimation of 5 mm, a pitch of 2, and a reconstruction interval of 5 mm. All macroscopically evident metastases were recorded at autopsy. CT images were independently reviewed by 10 radiologists and compared with pathologic results. Alternate slices in the dog with the most metastases were microscopically examined in their entirety. Pathologic examination of the lungs revealed 132 macroscopically evident pulmonary metastases, of which 74 (56%) were detected by at least one reader. Forty-four of the 99 (44%) metastases of < or = 5 mm in diameter were detected by at least one reader compared with 30 of 33 (91%) metastases of > 5 mm in diameter (p < 0.0001). The 10 readers reported a total of 107 false positives. Complete microscopy of alternate slices in the dog with the most metastases (n = 68) revealed an additional 38 micrometastases of < or = 3 mm in diameter. None of the 32 micrometastases of < or = 1 mm were detected by CT. Helical CT has some limitations in the detection of pulmonary metastases.

References

Jun 1, 1991·Radiology·P CostelloD Blume
Sep 1, 1987·Radiology·M Peuchot, H I Libshitz
Sep 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H I PassJ A Roth
Mar 1, 1994·AJR. American Journal of Roentgenology·D V Paranjpe, C J Bergin
Dec 1, 1993·Radiology·J P HeikenM W Vannier
Jun 1, 1996·Radiology·A R WrightC M Turnbull

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Citations

Sep 23, 2010·General Thoracic and Cardiovascular Surgery·Jun Nakajima
Mar 11, 2010·Acta Veterinaria Scandinavica·Carolina C OtoniRenée L Amorim
Apr 13, 2005·American Journal of Veterinary Research·Lieve M De RyckeHenri van Bree
Apr 21, 2012·Journal of the American Veterinary Medical Association·Laura J ArmbrustMichael W Sanderson
Oct 24, 2007·The Annals of Thoracic Surgery·Jun NakajimaShinichi Takamoto
Oct 24, 2007·The Veterinary Clinics of North America. Small Animal Practice·Amy K LeBlanc, Gregory B Daniel
Mar 1, 2004·Veterinary and Comparative Oncology·J M LiptakS J Withrow
Aug 30, 2007·The Journal of Small Animal Practice·G A PoltonC A Burton
Mar 15, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kate AlexanderGuy Beauchamp
Dec 5, 2013·Journal of Surgical Oncology·Robert T Ripley, Robert J Downey
Feb 21, 2013·Veterinary and Comparative Oncology·M L OblakS Nykamp
Jan 18, 2006·Journal of Pediatric Surgery·Mark L KaytonMichael P LaQuaglia
Nov 25, 2004·The Annals of Thoracic Surgery·Alden M ParsonsLeonard A Parker
Nov 27, 2007·The Annals of Thoracic Surgery·Alden M ParsonsFrank C Detterbeck
Jul 10, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Tanya WrightDorothee Bienzle
Dec 25, 2003·Journal of Proteome Research·Li XiongFred Regnier

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