The detection of urethritis pathogens among patients with the male urethritis syndrome, genital ulcer syndrome and HIV voluntary counselling and testing clients: should South Africa's syndromic management approach be revised?

Sexually Transmitted Infections
V BlackD A Lewis

Abstract

To determine the prevalence of urethritis pathogens amongst male symptomatic urethritis (MUS) patients, genital ulcer (GUS) patients without urethritis symptoms and men requesting HIV testing at a voluntary counselling and testing (VCT) clinic. A prospective study was conducted in Johannesburg, South Africa. Men from the three groups were screened for urethritis pathogens using molecular tests. Culture for Neisseria gonorrhoeae and, initially, trichomoniasis was performed. Antimicrobial susceptibility testing was undertaken for ciprofloxacin on all gonococcal isolates; ciprofloxacin resistant isolates were screened for ceftriaxone resistance. 664 participants were recruited (438 MUS, 76 GUS and 158 VCT) over 2 years. Gonorrhoea was detected in 62.3% MUS, 15.8% GUS and 3.2% VCT participants. Chlamydial infection was detected in 19.3% MUS, 13.2% GUS and 8.2% VCT participants. Trichomoniasis was detected in 4.9% MUS, 19.7% GUS and 3.8% VCT participants. Mycoplasma genitalium infection was detected in 14.4% MUS, 13.2% GUS and 7.0% VCT participants. Ciprofloxacin resistance increased from 13.0% in the first year to 26.3% in the second year; all resistant isolates were susceptible to ceftriaxone. Urethritis pathogens, including Trich...Continue Reading

Citations

Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa E ManhartMatthew R Golden
Mar 17, 2012·Sexually Transmitted Diseases·Supriya D MehtaRobert C Bailey
Dec 15, 2010·Sexual & Reproductive Healthcare : Official Journal of the Swedish Association of Midwives·Leigh F JohnsonDavid J Coetzee
Sep 21, 2010·International Journal of STD & AIDS·M C Le RouxA A Hoosen
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Aug 2, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Koichiro WadaShingo Yamamoto

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