PMID: 7481097Aug 1, 1995

The determinant of severe cerebral dysfunction in patients undergoing emergency extracorporeal life support following cardiopulmonary resuscitation

Resuscitation
M KuroseH Terasaki

Abstract

We investigated the factors associated with cerebral dysfunction in patients undergoing extracorporeal life support (ECLS) following conventional advanced cardiac life support (ACLS). The subjects were 9 patients in whom ECLS was started following ACLS because of intractable cardiac arrest. We investigated whether the irreversibility of cerebral dysfunction during ECLS was related to the cardiopulmonary resuscitation (CPR) time, arterial pH and blood gases, hemoglobin concentration (Hb), peak arterial pressure (PAP) before the start of ECLS and total doses of epinephrine and sodium bicarbonate administered during CPR. Two of the 3 patients who recovered consciousness were weaned from ECLS and survived, while all 6 patients who did not recover from coma were not weaned and died. There was no difference in the CPR time, Hb and PAP before the start of ECLS along with total doses of epinephrine and sodium bicarbonate administered during CPR between the patients who recovered consciousness and those who did not. In addition, there was no difference in arterial pH and blood gases except the arterial oxygen tension (PaO2) between the groups. The PaO2 values before the start of ECLS in the patients who remained in coma ranged from 34 t...Continue Reading

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Citations

Apr 29, 1998·Journal of Critical Care·P B RichR H Bartlett
May 1, 1997·The New England Journal of Medicine·O Fruchter
Aug 27, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marilyn C MorrisVinay M Nadkarni
Feb 14, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Catherine K AllanPeter C Laussen
Aug 5, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J G YoungerR H Bartlett
Sep 23, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marcelo G CardarelliBartley Griffith
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Robert B KellyNeal J Thomas

Related Concepts

Anoxemia
Blood Gas Analysis
Diastolic Blood Pressure
Brain Ischemia
Psychogenic Coma
Medihaler-Epi
Cardiac Arrest
Eryhem
Hydrogen-Ion Concentration
Extracorporeal Membrane Oxygenation

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