The determinants of Chagas disease: connecting parasite and host genetics

Current Molecular Medicine
David A CampbellNancy R Sturm

Abstract

As a consequence of infection by Trypanosoma cruzi, 30% of victims may develop chronic Chagas disease, which presents a spectrum of pathology including cardiomyopathy, megacolon and megaesophagus. The outcome of infection in a particular individual is the result of a set of complex interactions among the host genetic background, environmental and social factors, and the genetic composition of the parasite, all of which can be complicated by mixed infections and re-infections. Initially we consider what is known about the genetic structure and biological properties of the protozoan. Currently, six distinct subgroups have been characterized by different combinations of four distinct genotypic classes. The recent demonstration of genetic exchange via non-meiotic cell fusion illustrates a mechanism by which maintained heterogeneous polyploidy may have been generated in these parasites. Subsequently, we consider factors in humans and in experimental mouse-infection and tissue culture models that have contributed to our understanding of the host's susceptibility or resistance to disease. Identification of the direct players in host-pathogen interactions at the establishment and chronic phases of the disease is perhaps the best hope o...Continue Reading

Citations

Aug 15, 2008·Parasitology·M RozasJ-C Dujardin
Sep 27, 2012·Parasitology·Laura Viviana Sánchez, Juan David Ramírez
Feb 28, 2007·The American Journal of Surgical Pathology·Guido IantornoVincenzo Villanacci
Oct 7, 2011·Clinical Microbiology Reviews·Caryn BernSusan P Montgomery
Jan 26, 2011·BMC Genomics·Laura I Ruvalcaba-Trejo, Nancy R Sturm
May 4, 2013·BMC Research Notes·Marcela SegattoAndréa Mara Macedo
Dec 15, 2010·PLoS Neglected Tropical Diseases·Juan David RamírezCarlos A Morillo
Mar 27, 2012·PLoS Neglected Tropical Diseases·Florencia del PuertoKenji Hirayama
Aug 23, 2011·PloS One·Renata T SouzaJosé Franco da Silveira
Jul 7, 2005·Genetics·Scott J WestenbergerNancy R Sturm
Dec 10, 2009·The American Journal of Tropical Medicine and Hygiene·Michael D LewisMichael A Miles
Feb 5, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Christian BarnabéSimone Frédérique Brenière
Jul 15, 2015·Expert Review of Anti-infective Therapy·Louisa A MessengerCaryn Bern
Oct 14, 2008·Stress : the International Journal on the Biology of Stress·Leony Cristina CaetanoJosé Clóvis do Prado
May 4, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Susan IenneBianca Zingales
Dec 8, 2009·Enfermedades infecciosas y microbiología clínica·María Flores-ChávezCarmen Cañavate
Jun 9, 2009·International Journal for Parasitology·Julio César CarranzaBianca Zingales
Mar 7, 2007·Cytokine & Growth Factor Reviews·Wilson SavinoSusana Gea
Feb 3, 2007·Experimental Parasitology·Aurélio PedrosoBianca Zingales
Sep 5, 2015·Journal of the American College of Cardiology·Roberto Kalil-Filho
Jan 31, 2006·International Journal for Parasitology·Scott J WestenbergerDavid A Campbell
Mar 17, 2010·Acta Tropica·Fernando Abad-FranchChristopher J Schofield
Aug 22, 2009·Acta Tropica·Nancy R Sturm, David A Campbell
Feb 22, 2012·FEMS Microbiology Reviews·Maria Cecilia Fernandes, Norma W Andrews
Feb 6, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Claudia Patricia HerreraSimone Frédérique Brenière
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bianca ZingalesNancy R Sturm
Jan 24, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rosa M CorralesMiguel A Basombrio

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