The determination of neuronal fate in the cerebral cortex.

Trends in Neurosciences
Susan K McConnell

Abstract

During the embryonic development of the cerebral cortex, young neurons migrate out into characteristic laminar positions and form specific axonal connections with other neurons. The birthdate of a neuron, and its tangential location in the ventricular zone, can serve as markers that predict its normal laminar fate and pattern of connectivity. In order to test whether cells of the developing cerebral cortex are committed to their normal fates, several types of transplantation experiment have challenged young cortical neurons to alter their identities or connections in novel environments. Other recent experiments have employed retroviral vectors to trace neuronal lineages in the cortex. Together, these studies suggest that phenotypic commitment involves a series of decisions. Certain developmental restrictions--for example, commitment to a laminar identity--may occur at or around the time of the cell's final mitotic division, whereas the refinement of area-specific axonal projections occurs as the neuron differentiates within the cortex.

References

Jul 28, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D H Hubel, T N Wiesel
Dec 25, 1976·The Journal of Comparative Neurology·V S Caviness
Mar 1, 1989·Trends in Neurosciences·D F Ready
Jun 10, 1988·Science·C Kenyon
Jul 8, 1988·Science·P Rakic
Jan 1, 1985·Vision Research·C D Gilbert, T N Wiesel
Jan 1, 1984·Somatosensory Research·L YurkewiczE G Jones
Oct 1, 1981·The Journal of Comparative Neurology·U C Dräger
Feb 1, 1963·The Journal of Comparative Neurology·S FUJITA

❮ Previous
Next ❯

Citations

Feb 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H V VintersW D Shields
Sep 15, 1990·Experientia·C Walsh, C L Cepko
Jan 1, 1993·Biological Psychiatry·R A ShepherdJ J McGrath
Oct 1, 1992·Developmental Biology·A Repka, R Adler
Oct 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J WiedehageE Buse
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A BruscoV Flores
Aug 1, 1994·Mechanisms of Development·P IacopettiF Cremisi
Mar 29, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Philip T. Quinlan
Jan 1, 2011·Translational Psychiatry·J J McGrathG Gibson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D LeiferS A Lipton
May 17, 2012·Genes & Development·Jenny Hsieh
Jan 1, 1990·The European Journal of Neuroscience·S. B. Dunnett
Jan 1, 1994·The European Journal of Neuroscience·M Götz, J Bolz
Jan 1, 1990·Journal of Cognitive Neuroscience·H P Killackey
Sep 4, 2001·Developmental Neuropsychology·S J WebbC A Nelson
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory J WoodheadAnjen Chenn
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·F J LiveseyC L Cepko
Jan 29, 1996·Brain Research·P IacopettiF Cremisi
Sep 11, 2012·Neuron·Jie HeWilliam A Harris
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Matthew G Voas, Ilaria Rebay
Jul 2, 2003·The Journal of Comparative Neurology·Viorica Pencea, Marla B Luskin
Oct 22, 1993·Proceedings. Biological Sciences·K J FristonR S Frackowiak
Oct 10, 2003·Nature·Bret J Pearson, Chris Q Doe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.