The Determination of Rod and Cone Photoreceptor Fate

Annual Review of Vision Science
Constance L Cepko

Abstract

Photoreceptors have been the most intensively studied retinal cell type. Early lineage studies showed that photoreceptors are produced by retinal progenitor cells (RPCs) that produce only photoreceptor cells and by RPCs that produce both photoreceptor cells and other retinal cell types. More recent lineage studies have shown that there are intrinsic, molecular differences among these RPCs and that these molecular differences operate in gene regulatory networks (GRNs) that lead to the choice of the rod versus the cone fate. In addition, there are GRNs that lead to the choice of a photoreceptor fate and that of another retinal cell type. An example of such a GRN is one that drives the binary fate choice between a rod photoreceptor and bipolar cell. This GRN has many elements, including both feedforward and feedback regulatory loops, highlighting the complexity of such networks. This and other examples of retinal cell fate determination are reviewed here, focusing on the events that direct the choice of rod and cone photoreceptor fate.

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Citations

Mar 14, 2018·Diagnostics·Charlotte A Hall, Robert P Chilcott
Jan 27, 2018·Molecular Biology and Evolution·Kaia AchimDetlev Arendt
May 10, 2018·Integrative and Comparative Biology·Gerhard Schlosser
Jan 10, 2020·Development·Carlos Perez-CervantesIvan P Moskowitz
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shuting LiuMengqing Xiang
Sep 18, 2018·Annual Review of Vision Science·Ye Sun, Lois E H Smith
Oct 20, 2020·Frontiers in Bioengineering and Biotechnology·Fang-Yuan HuJi-Hong Wu
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yujin Lee, Jaewook Yang
Jul 25, 2021·International Journal of Molecular Sciences·Darya V TeleginaNataliya G Kolosova

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BETA
transgenic

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EELPOT

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