The determination of the amino acid sequence in the fast atom bombardment mass spectra of dipeptides

Biomedical & Environmental Mass Spectrometry
W Kulik, W Heerma

Abstract

The positive ion fast atom bombardment mass spectra of dipeptides all exhibit the MH+ ion as the most abundant one. Direct identification of the N-terminal amino acid in the mass spectrum is not possible because of the absence of its acylium ion. Fortunately the identification of the C-terminus is often possible because of the occurrence of the protonated C-terminal amino acid as a result of MH+ ion fragmentation. In all cases, including those where the abundance of this C-terminal ion is too low for identification, the metastable ion spectrum of the MH+ ion provides sufficient information for an unequivocal sequence determination.

Citations

Jan 1, 1993·Annals of Neurology·M A LovellW R Markesbery
Jan 18, 2006·Journal of the American Society for Mass Spectrometry·Hao-Yang WangLong Lu
Jan 6, 2001·Journal of the American Society for Mass Spectrometry·A G Harrison
Oct 22, 2002·Journal of the American Society for Mass Spectrometry·Alex G Harrison
Jan 1, 1991·Preparative Biochemistry·R Seidl, W Schaefer
Oct 1, 1989·Biomedical & Environmental Mass Spectrometry·W Kulik, W Heerma
Feb 11, 2003·Journal of Mass Spectrometry : JMS·Alex G Harrison
Jun 22, 2000·Journal of Mass Spectrometry : JMS·A G HarrisonY P Tu
Feb 20, 2007·Analytical Chemistry·Francesco PingitoreJay D Keasling

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