The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

BMC Cancer
Ji-Jin YaoYing Sun

Abstract

Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local control for advanced T stage (T3-4) in the intensity-modulated radiation therapy (IMRT) era. We aim to evaluate whether RTI affects local control for T3-4 NPC treated with definitive IMRT. In this observational prospective study, 447 T3-4 NPC patients treated with IMRT plus concurrent chemotherapy were included. All patients completed the planned radiotherapy course, and RTI was defined as the actual time taken to finish the prescribed course of radiotherapy minus the planned radiotherapy time. Receiver operating characteristic (ROC) curve was used for determined the cutoff point of RTI. The effects of RTI on local control were analyzed in multivariate analysis. At 5 years, the local relapse-free survival (LRFS) and overall survival (OS) rates were 93.7 and 85.7%, respectively. The cutoff RTI for LRFS was 5.5 days by ROC curve. Compared to patients with RTI >  5 days, patients with RTI ≤ 5 days had a significantly lower rate of LRFS (97% vs. 83%; P < 0.001). In multivariate analysis, RTI was a risk factor independently associa...Continue Reading

References

Mar 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F SchwaiboldJ Wenger
Jan 1, 1988·Acta Oncologica·H R WithersB Maciejewski
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·Q T LeT L Phillips
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·D L KwongP M Wu
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, R Chappell
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S KiesE E Vokes
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeKaren K Fu
Jun 18, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter C LevendagPeter J C M Nowak
Jun 11, 2004·The New England Journal of Medicine·Jin-Ching LinRong-San Jiang
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Shyh-An YehEng-Yen Huang
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Hideya YamazakiMasashi Chatani
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Faye M JohnsonBonnie S Glisson
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Bertrand BaujatUNKNOWN MAC-NPC Collaborative Group
Feb 25, 2009·The Laryngoscope·Ming-Yuan ChenMing-Huang Hong
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy LeeK Kian Ang
Jan 28, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jeffrey Kit Loong TuanJoseph Tien Seng Wee
Sep 22, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gang PengGang Wu
Sep 25, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rui GuoJun Ma
Oct 26, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J L-Y ChenC-W Wang

❮ Previous
Next ❯

Citations

Dec 9, 2020·Expert Review of Anticancer Therapy·Rituraj Upadhyay, Abhishek Shankar
Dec 5, 2020·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Chunhui HanAn Liu
Jun 12, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ya-Nan JinLiang-Ping Xia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved