May 29, 2012

The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin

Journal of Controlled Release : Official Journal of the Controlled Release Society
Shu LiuAkira Yamamoto

Abstract

The aim of the present study was to develop novel insulin-loaded microneedle arrays (MNs) fabricated from hyaluronic acid (HA), and characterize their applicability in the transdermal delivery of insulin. The shape of MNs was observed via scanning electron microscopy. The characteristics of these novel insulin-loaded MNs, including hygroscopy, stability, drug release profiles, and dissolution properties, were evaluated from a clinical application point-of-view. Transepidermal water loss (TEWL) was measured to investigate the piercing properties of MNs, and the recovery of the skin barrier after the removal of MNs to confirm their safety. Additionally, the transdermal absorption of insulin from MNs was examined via an in vivo absorption study in diabetic rats. The length of MNs was 800 μm with a base diameter of 160 μm and a tip diameter of 40 μm. MNs were found to maintain their skin piercing abilities for at least 1h, even at a relative humidity of 75%. After storing insulin-loaded MNs for a month at -40, 4, 20, and 40 °C, more than 90% of insulin remained in MNs at all temperatures, indicating that insulin is highly stable in MNs at these storage conditions. It was also found that insulin is rapidly released from MNs via an i...Continue Reading

  • References39
  • Citations56

References

  • References39
  • Citations56

Citations

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Buffers
Carbohydrate nutrients
Drug Delivery Systems
Tissue Membrane
Galactose Measurement
Insulin, Beef
Glucose Measurement
Dextrin
Citricum acidum, citric acid, homeopathic preparation

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