PMID: 3770601Aug 1, 1986Paper

The development and evaluation of a 125I radioimmunoassay for the measurement of LSD in body fluids

Forensic Science International : Synergy
A H SteadA C Moffat

Abstract

A radioimmunoassay (RIA) has been developed for the direct detection of LSD in biological fluids. The radiotracer, (+)-2-[125I]iodo-LSD, allows the use of gamma-counting rather than the liquid scintillation counting currently used for existing 3H radioimmunoassays. The assay is specific for LSD and very closely related compounds. It is inexpensive, sensitive, simple to use and small volumes of samples (50 microliter) can be assayed directly without the need for any time-consuming extraction procedures. The cut-off levels are 1.2 ng/ml in blood and 3.0 ng/ml in urine. The results obtained using the 125I assay described in this work compare very favourably with those obtained using the 3H assay currently used by Home Office Forensic Science Laboratories. The advantages of the assay make it a most appropriate method for the routine screening of LSD in biological samples of forensic interest.

References

May 26, 1976·Journal of Chromatography·J ChristieJ M Wiles
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Feb 1, 1985·Analytical Biochemistry·P R HartigS A Hirschman
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Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·G EngelJ M Palacios

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Citations

May 9, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·H HojaG Lachâtre
Aug 4, 1997·Forensic Science International : Synergy·F Musshoff, T Daldrup
Jun 6, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·M FrostG Blaschke
Feb 1, 1997·Occupational and Environmental Medicine·G Gemne
Feb 26, 2010·Die Naturwissenschaften·Jan M PestkaMichael Amling

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