PMID: 2494634Jan 1, 1989Paper

The development and specificity of cytotoxic cells in cattle immunized with autologous or allogeneic Theileria annulata-infected lymphoblastoid cell lines

Parasite Immunology
E A InnesR L Spooner

Abstract

Two groups of animals were immunized with either 10(6) autologous or 10(6) allogeneic Theileria annulata-infected lymphoblastoid cells cultured in vitro. The development and specificity of cytotoxic cells generated in vivo were measured throughout immunization and challenge using a panel of target cells that were either Theileria-infected or uninfected blast cells of known bovine lymphocyte antigen (BoLA) specificities. After inoculation of the cell lines the two groups showed distinct differences in both their clinical responses and the target specificity of the cytotoxic cells detected. The allogeneic T. annulata cell line recipients showed a very mild clinical response, and on day 9 after inoculation a strong cytotoxic response was detected. The response appeared to be directed against the allogeneic major histocompatibility complex (MHC) antigens of the inoculated cell line in some form of graft rejection response. By day 23 the predominant cytotoxic response was directed against the recipient animals' own cells infected with the parasite. In contrast, the autologous T. annulata cell line recipients showed very severe clinical reactions, and low levels of cytotoxicity were detected. The cytotoxicity was directed against par...Continue Reading

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Citations

Nov 15, 1989·Veterinary Immunology and Immunopathology·E J GlassC G Brown
Jun 1, 1992·Veterinary Immunology and Immunopathology·M Kachani, R L Spooner
Nov 1, 1992·Veterinary Immunology and Immunopathology·M KachaniR L Spooner
Feb 1, 1992·Veterinary Parasitology·S S Chaudhri, G Subramanian
Feb 6, 2007·Parasitology·W I Morrison, D J McKeever
May 23, 2003·Infection and Immunity·Lauren M StaskaTimothy V Baszler
Mar 26, 1998·Tropical Animal Health and Production·J S AhmedJ Gerdes
Jan 31, 2009·Vaccine·Ulrike Seitzer, Jabbar Ahmed
May 24, 2008·Parasite Immunology·N D MachughW I Morrison
Oct 1, 1989·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·J S AhmedE Schein
Sep 21, 2016·Parasite Immunology·V Nene, W I Morrison
Apr 5, 2008·Innate Immunity·Jabbar S AhmedUlrike Seitzer
Jan 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M D RichardsonG S Shankland
Mar 26, 1998·Tropical Animal Health and Production·J D CampbellE J Glass
Feb 1, 1995·Clinical and Experimental Immunology·J D CampbellE J Glass

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