The development and the topographic organization of the retinal ganglion cell layer in Bufo marinus

Experimental Brain Research
V S Nguyen, C Straznicky

Abstract

The number and distribution of neurons in the retinal ganglion cell layer were studied from the metamorphic climax to adulthood in the toad Bufo marinus. Retinal wholemounts stained with cresyl violet showed that total neuron numbers increased from 55,000 at metamorphic climax to about 950,000 in adult animals. During the same time the entire retinal area increased 46-fold from an average 3.4 mm2 to 157 mm2. The morphological character of the neurons and their density across the retina changed during development. In metamorphosing animals, the neurons of the ganglion cell layer had a uniform appearance and their density increased slightly from the centre to the dorsal ciliary margin. After metamorphosis a high neuron density area, the visual streak, evolved in the retinal centre, resulting in the formation of a 6 to 1 density gradient from the visual streak out to the dorsal and ventral retinal poles in adult animals. Optic fibre numbers in juvenile and adult optic nerves were estimated to be 330,000 and 745,000, respectively, corresponding to similar ganglion cell numbers. One optic nerve was sectioned in a few animals and 4 weeks later the number of intact neurons--assumed to be displaced amacrine cells (DA)--was estimated. T...Continue Reading

Citations

Apr 1, 1993·Cell and Tissue Research·R GábrielC Straznicky
Sep 18, 1992·Brain Research. Developmental Brain Research·B Zhu, C Straznicky
Dec 3, 2015·Journal of Integrative Neuroscience·Igor I Pushchin, Nataliya E Zyumchenko
Nov 30, 2007·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Shaun P Collin
Aug 22, 2001·Microscopy Research and Technique·E A Debski
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ben D FulcherXiao-Jing Wang
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
May 18, 2019·The British Journal of Ophthalmology·Kritchai VutipongsatornKyoko Ohno-Matsui
Nov 30, 2019·Nature Reviews. Neuroscience·Tom BadenPhilipp Berens

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